With our patented compression technology, The Compresstome® overcomes these issues and can produce slices that have

  • More Live cells: Compression stabilizes the tissue, producing much more living cells on live tissues.
  • Smooth sections: tissue stabilization + Auto-Zero-Z® = No artifacts
  • Easy to orient: The agarose embedding method and specimen tube support provides a easy way to orient the flimsy tissue for sectioning.

Spinal Cord tissues have the following characteristics that makes it difficult for traditional Vibratomes to section

  • Variability in tissue texture: The spinal cord contains several different types of neural tissue, such as white matter, gray matter, and nuclei, each with different textures and densities. This variability can make it challenging to produce uniform sections with a vibratome, and dense regions may cause the blade to skip or produce uneven section thickness.
  • Presence of delicate structures: The spinal cord contains several delicate structures, such as the meninges, blood vessels, and neural fibers, that can be easily damaged during sectioning. The vibratome blade may tear or crumple these structures, leading to unusable or distorted sections.
  • Soft and pliable tissue: The soft and pliable nature of spinal cord tissue can make sectioning challenging

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Real lab examples


Premkumar LS. Methods Used for Studying TRP Channel Functions in Sensory Neurons. In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 13. PMID: 22593954. Download PDF

Jeffry JA, Yu SQ, Sikand P, Parihar A, Evans MS, Premkumar LS. Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS One. 2009 Sep 15;4(9):e7021. PMID: 19753113; PMCID: PMC2737142 Download PDF

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