Compresstome® Lab Feature: The Albelda Lab at the University of Pennsylvania

Meet Dr. Astero Klampatsa, who uses the Compresstome vibratome for thoracic cancer research at the University of Pennsylvania!

The Compresstome® Vibratome in the Albelda Lab:

Dr. Astero Klampatsa works at the Penn Center for Lung Biology, Division of Pulmonary, Allergy and Critical Care Medicine at Penn. Her lab is headed by principle investigator Dr. Steve Albelda, who is interested in understanding the immune microenvironment of mesothelioma and lung cancer, and on developing CAR T-cell therapies for these types of malignancies.

Using lung slices from patient tumors, Dr. Klampatsa studies their endogenous immune components. Precision-cult lung slices (PCLS) made with the Compresstome vibratome allow her to treat samples with novel therapies, like CAR T cells or antibodies, ex vivo and measure response.

Here, we would like to showcase some of Dr. Klampatsa’s amazing work using precision-cut lung slices. Note that tissue slices made with the Compresstome vibratome can be used for physiological studies, as well as for H&E and fluorescent protein staining.

Albelda Lab doctor using Compresstome
Figure 1. Dr. Astero Klampatsa by a Compresstome VF-200-0Z vibratome, which is kept under the hood so that tissue sectioning may be completed under aseptic conditions.
Albelda Lab H&E stain
Figure 2. H&E stain of a mesothelioma tumor, sectioned at 500µm.
Albelda Lab confocal microscopy
Figure 3. Confocal microscopy image showing localization of T cells within a fibrotic mesothelioma tumor, following CAR T cell therapy (Blue: DAPI, Red: CD8, Green: CD90).

To find out more about Dr. Klampatsa’s work at Penn, visit:

https://www.researchgate.net/profile/Astero_Klampatsa

Share
Related Posts
Compresstome Vibrating Microtomes

Customer Testimonials at Precisionary Instruments

At Precisionary Instruments, we have almost two decades of customer service experience and microtome expertise. We have strategically built our brand to be trusted in

Education

How sex hormones sculpt the brain

Sex hormones are hormones that play a role in the development and maintenance of the male and female reproductive systems, as well as secondary sexual

Compresstome Vibrating Microtomes

Introduction to Patch-Clamp Electrophysiology

Electrophysiology is the study of the electrical properties of biological cells and tissues, and how these properties generate and propagate electrical signals in the body.

Call Now Button617-682-0586