Compresstome® Lab Feature: The Albelda Lab at the University of Pennsylvania

Meet Dr. Astero Klampatsa, who uses the Compresstome vibratome for thoracic cancer research at the University of Pennsylvania!

The Compresstome® Vibratome in the Albelda Lab:

Dr. Astero Klampatsa works at the Penn Center for Lung Biology, Division of Pulmonary, Allergy and Critical Care Medicine at Penn. Her lab is headed by principle investigator Dr. Steve Albelda, who is interested in understanding the immune microenvironment of mesothelioma and lung cancer, and on developing CAR T-cell therapies for these types of malignancies.

Using lung slices from patient tumors, Dr. Klampatsa studies their endogenous immune components. Precision-cult lung slices (PCLS) made with the Compresstome vibratome allow her to treat samples with novel therapies, like CAR T cells or antibodies, ex vivo and measure response.

Here, we would like to showcase some of Dr. Klampatsa’s amazing work using precision-cut lung slices. Note that tissue slices made with the Compresstome vibratome can be used for physiological studies, as well as for H&E and fluorescent protein staining.

Albelda Lab doctor using Compresstome
Figure 1. Dr. Astero Klampatsa by a Compresstome VF-200-0Z vibratome, which is kept under the hood so that tissue sectioning may be completed under aseptic conditions.
Albelda Lab H&E stain
Figure 2. H&E stain of a mesothelioma tumor, sectioned at 500µm.
Albelda Lab confocal microscopy
Figure 3. Confocal microscopy image showing localization of T cells within a fibrotic mesothelioma tumor, following CAR T cell therapy (Blue: DAPI, Red: CD8, Green: CD90).

To find out more about Dr. Klampatsa’s work at Penn, visit:

https://www.researchgate.net/profile/Astero_Klampatsa

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