How the Compresstome® Compares to Other Market Slicers

We listened to scientists around the world on what they would like in a tissue slicer, and we implemented those features into the latest Compresstome® models. Here is how our slicers compare to those on the market.

Other Tissue Slicers

Vibrating microtome slicers are historically the standard source for laboratory and industry slicing. The only adjustable components include vibration amplitude, speed of blade movement, and the blade angle.

There are 3 key disadvantages of vibrating slicers:

1. Extremely time consuming (slow cutting speed results in worse slice health)

2. Faster cutting speed causes chattermarks

3. Some tissues are difficult to cut without tearing or shearing

Compresstome® Slicers

Our Compresstome® slicers help overcome all 3 limitations of vibrating microtome cutters!

Top reasons to choose Compresstome®:

1. Generate fresh tissue sections 5 times faster

2. Can cut larger sized tissue sections

3. Cutting difficult tissues that are fibrous

4. No more chatter marks or shearing of tissue

What is the advantage of the Compresstome® compared to other slicers?

Below are the empirical results of tests we ran in the lab to visually show how the results of tissue cut with the Compresstome® compare to sections made with another top vibrating microtome on the market.


Compresstome® VF-300-0Z

Other market vibrating slicer





Compresstome® VF-300-0Z

Other market vibrating microtome



Compresstome® VF-300-0Z

Other market vibrating microtome

In summary:

  • Sections made with the Compresstome® are even, and are free of chattermarks. At a slower cutting speed, sections with a market leading vibrating microtome have uneven surfaces and significant chattermarks.
  • Slice cutting speed is much faster with the Compresstome®—you can complete your job quicker!
  • Overall, the Compresstome® produces superior slices with high quality surfaces for your experiments.

The Compresstome® vibrating microtome are tissue slicers that have been designed and patented by Precisionary Instruments to achieve healthier and smoother sections for better research results. Using an advanced agarose-embedding technique, both fresh and fixed specimens can be completely stabilized during the cutting process, which yields slices with consistent thicknesses to help scientists obtain reliable data.

What makes the Compresstome® better? For fresh tissue, our vibrating microtome cuts faster to give you slices with an increased number of healthy cells—making your electrophysiology and imaging experiments easier. For fixed tissue, the Compresstome® can cut anywhere from 4 µm- to 500 µm-thick slices, without chatter marks or vibration artifacts. The faster, automated process of slicing helps you save time in obtaining fixed tissue sections for immunohistochemistry or in-situ hybridization experiments.