Compresstome® VF-500-0Z

SKU: VF-500-0Z

Covered by a 5-year warranty (included!)

The Compresstome® VF-500-0Z vibrating microtome is our recommended tissue slicer for electrophysiology. It produces superior brain slices with a higher number of viable neurons for patch-clamp electrophysiology.

  • Preserves surface neurons to significantly improve patch clamping results for electrophysiology
  • Slices over 5x faster than other market vibrating microtomes
  • Patented compression technology and agarose embedding process tissue and eliminates chattermarks
  • Fully automated slicing!
  • Auto Zero-Z® technology reduces Z-axis deflection to <1 μm
  • Light footprint for increased portability
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Key Features of the compresstome® VF-500-0Z vibrating microtome

The VF-500-0Z is designed by our engineers with a more durable vibrating head unit. Check out its key features:

Benefits of slight compression for tissue slicing

When using the Compresstome®, you will embed your tissue in agarose inside a specimen tube. The open end of the specimen tube has a slightly tapered edge. As tissue and agarose cross the edge of the tube, it gets slightly compressed. This compression helps stabilize the tissue during sectioning, and allows the Compresstome® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.

Don’t worry–The agarose embedding does not decrease cell viability. Rather, it enhances cell survival because of tissue stability. The agarose solution is quickly cooled down with a chilling block during sample preparation. With the Compresstome®, your tissue can be sectioned faster because of the agarose-induced stability. As a result, cells are never without oxygenation for a long time, and the added stability of the compression significantly reduces any blade damage.

Download Auto Zero-Z® explanations

What is Auto Zero-Z® technology? How Does it benefit tissue slicing?

Compresstome® slicer models marked with “-0Z” mean that the model has our patented Auto Zero-Z® technology. These vibrating heads are precisely aligned to eliminate vibrations in the Z-axis. Auto Zero-Z® technology helps reduce damage to surface cells on live tissue samples, and further reduce chattermarks on thin sections for improved imaging results.

Equivalent to the vibratome Vibrocheck, but you don’t have to calibrate each time you cut which saves you time. Auto Zero-Z® is also included in all of our Compresstome® vibrating microtomes, so it’s no additional cost.


Produce healthier slices for patch-clamp, field recordings, and calcium imaging for brain, heart, and kidney tissue slices.

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Precision-Cut Tissue Slices

Get higher quality live tissue slices for studies of lung, liver, kidney, gut, spleen, and reproductive tissues. Excellent for enzyme or toxicology research.

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Organotypic Tissue Slice Culture

Use the Compresstome® vibratome for organotypic brain slice cultures and tumor slice cultures.

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Download Tech Specs
Technical Specifications for Compresstome® VF-500-0Z
Advance Speed0-4 mm/s, adjustable
Return Speed8 mm/s, fixed
Vibration Frequency0-70 Hz, adjustable
Vibration Amplitude1.5 mm, fixed
Z-Axis Vibration~0 µm
Compatible Cutting BladesDouble-edge stainless steel blades
Ceramic blades
Tungsten carbide blades
Cutting Angle15 degrees, fixed
Thickness AdjustmentAutomatic, digital
Micrometer Resolution1 µm
Maximum Tissue Diameter15.5 mm
20 mm
Maximum Tissue Length23 mm
Slice Thickness Range2 µm to 1000 µm
(Quality tested to cut below 10 µm)
Cutting ModesSingle or continuous, selectable
Buffer Tray Size110 x 60 x 30 mm
Power SourceDC 12V
Power Consumption4W
Dimensions (L x W x H)330 x 250 x 200 mm
Weight7 kg

About the compresstome® VF-500-0Z

Comparing Compresstome® models

References & Applications

Warranty & Service plans

Download Warranty & service plan


At Precisionary Instruments, we stand firmly behind the quality of our Compresstome® vibrating microtomes. Starting July 1, 2022, we will be offering a 5year warranty for all new Compresstome® units purchased on that date and after. The 5year warranty is included with each Compresstome® tissue slicer purchase (no additional fees)! Our warranty includes repairs, parts, labor, and shipping. This new 5year warranty program applies only to these Compresstome® models: VF-210-0Z, VF-310-0Z, and VF-500-0Z.

After the end of the warranty period, we also offer an Annual Service Agreement or plan to take care of your microtome for years to come!

Annual service plans

Precisionary Instruments offers an annual service agreement that can be purchased. The purchase must take place within the five years following Compresstome® delivery. Each subsequent annual service plan agreement purchase must be completed within the prior year’s service coverage. An annual service plan agreement cannot be purchased if there is a gap in annual service coverage. 

The annual service plan agreement is detailed as follows:

Product LineWarrantyWhat is included
Compresstome® vibrating microtomes:

  • VF-210-0Z

  • VF-310-0Z

  • VF-500-0Z

5-Year WarrantyIncludes parts, accessories, consumables, shipping fees, and labor.
Annual Service BASIC Plan

  • Precisionary Instruments covers all repair labor fees and maintenance costs under the Annual Service Agreement.

  • Precisionary Instruments covers all cost of parts, accessories, or shipping fees.

  • In summary, one (1) annual Basic Plan provides one (1) extended year of warranty.

Annual Service PREMIUM Plan

  • Precisionary Instruments covers all repair labor fees and maintenance costs under the Annual Service Agreement.

  • Precisionary Instruments covers all cost of parts, accessories, or shipping fees.

  • In summary, one (1) annual Basic Plan provides one (1) extended year of warranty.

  • Includes one (1) ship back to company for full preventative maintenance.

Consumables for compresstome vibrating microtome

parts & accessories for compresstome vibrating microtome