Meet Dr. Astero Klampatsa
, who uses the Compresstome vibrating microtome for thoracic cancer research at the University of Pennsylvania!The Compresstome® Vibrating Microtome in the Albelda Lab:
Dr. Astero Klampatsa works at the Penn Center for Lung Biology, Division of Pulmonary, Allergy and Critical Care Medicine at Penn. Her lab is headed by principle investigator Dr. Steve Albelda
, who is interested in understanding the immune microenvironment of mesothelioma and lung cancer, and on developing CAR T-cell therapies for these types of malignancies.
Using lung slices from patient tumors, Dr. Klampatsa studies their endogenous immune components. Precision-cut lung slices (PCLS) made with the Compresstome vibrating microtome allow her to treat samples with novel therapies, like CAR T cells or antibodies, ex vivo and measure response
Here, we would like to showcase some of Dr. Klampatsa’s amazing work using precision-cut lung slices. Note that tissue slices made with the Compresstome vibrating microtome can be used for physiological studies, as well as for H&E and fluorescent protein staining.Figure 1.
Dr. Astero Klampatsa by a Compresstome VF-200-0Z vibrating microtome, which is kept under the hood so that tissue sectioning may be completed under aseptic conditions.Figure 2.
H&E stain of a mesothelioma tumor, sectioned at 500µm.Figure 3
. Confocal microscopy image showing localization of T cells within a fibrotic mesothelioma tumor, following CAR T cell therapy (Blue: DAPI, Red: CD8, Green: CD90).
To find out more about Dr. Klampatsa’s work at Penn, visit:https://www.researchgate.net/profile/Astero_Klampatsa
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