Fixed brain refers to the brain tissue that has been preserved and stabilized through a process called fixation. It is an important tool in neuroscience research, allowing scientists to study the structure and function of the brain at a microscopic level. Tissue sections are needed to study fixed brain tissue as they provide a thin and flat sample that can be easily sliced and observed under a microscope. This allows researchers to investigate the cellular and molecular mechanisms underlying various brain functions, such as learning, memory, and behavior, and to identify changes that occur in neurological disorders.
Not sure which model is right for your needs?
Have you wondered how one mouse brain may be used for multiple experiments? Come discover the strategy behind using animal tissues for multi-use research experiments, so that your tissue samples can go further. Dr. Yiying Zhang from Harvard Medical School and Massachusetts General Hospital is our guest webinar speaker. For this Precisionary webinar, Dr. Zhang will discuss a “3D” use of animal tissues in planning experimental designs in academic research.
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Driessens SLW, Galakhova AA, Heyer DB, Pieterse IJ, Wilbers R, Mertens EJ, Waleboer F, Heistek TS, Coenen L, Meijer JR, Idema S, de Witt Hamer PC, Noske DP, de Kock CPJ, Lee BR, Smith K, Ting JT, Lein ES, Mansvelder HD, Goriounova NA. Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types. Nat Commun. 2023 Jul 13;14(1):4188. PMID: 37443107; PMCID: PMC10345092. Download PDF
Egawa K, Watanabe M, Shiraishi H, Sato D, Takahashi Y, Nishio S, Fukuda A. Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model. Sci Rep. 2023 Apr 17;13(1):5685. PMID: 37069177; PMCID: PMC10110603. Download PDF
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