• without chattermarks
  • with consistent thicknesses
  • At a faster speed
  • At as thin as 4 um

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VF-510-0Z

Compresstome vibrating microtome

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Real lab examples

“3D” use of animal tissues in experimental design

Have you wondered how one mouse brain may be used for multiple experiments? Come discover the strategy behind using animal tissues for multi-use research experiments, so that your tissue samples can go further. Dr. Yiying Zhang from Harvard Medical School and Massachusetts General Hospital is our guest webinar speaker. For this Precisionary webinar, Dr. Zhang will discuss a “3D” use of animal tissues in planning experimental designs in academic research.

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From two-dimensional to three-dimensional histopathology using a Compresstome®

Dr. Wong shares how he built a custom-made Compresstome® for high-speed histological 3D imaging of whole organs like brains.

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Interactions between Saturated Fat, Cytokines, and Microglia in the Ventral Striatum

Dr. Fordahl will highlight how proinflammatory cytokines alter dopamine terminal function, and how increasing dietary fat intake may enhance microglial activity.

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The locus coeruleus (LC) mediates behavioral flexibility

Dr. Greta Vargova is going to present their most recent publication, in which they show the link between locus coeruleus activity and behavioral flexibility.

References

Booeshaghi AS, Yao Z, van Velthoven C, Smith K, Tasic B, Zeng H, Pachter L. Isoform cell-type specificity in the mouse primary motor cortex. Nature. 2021 Oct;598(7879):195-199. Epub 2021 Oct 6. PMID: 34616073; PMCID: PMC8494650. Download PDF

Driessens SLW, Galakhova AA, Heyer DB, Pieterse IJ, Wilbers R, Mertens EJ, Waleboer F, Heistek TS, Coenen L, Meijer JR, Idema S, de Witt Hamer PC, Noske DP, de Kock CPJ, Lee BR, Smith K, Ting JT, Lein ES, Mansvelder HD, Goriounova NA. Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types. Nat Commun. 2023 Jul 13;14(1):4188. PMID: 37443107; PMCID: PMC10345092. Download PDF

Egawa K, Watanabe M, Shiraishi H, Sato D, Takahashi Y, Nishio S, Fukuda A. Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model. Sci Rep. 2023 Apr 17;13(1):5685. PMID: 37069177; PMCID: PMC10110603. Download PDF

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