Guinea pigs are often used as animal models in research for a range of diseases and conditions, including respiratory infections, cardiovascular disease, and neurological disorders. They are also used to study pharmacokinetics and pharmacodynamics of drugs and vaccines, as well as to develop diagnostic tests. Guinea pigs have a similar physiology to humans, making them a valuable model for preclinical research.
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Ahn S, Maarsingh H, Walker JK, Liu SW, Hegde A, Sumajit HC, Kahsai AW, Lefkowitz RJ. Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models. J Clin Invest. 2023 Jul 11:e167337. Epub ahead of print. PMID: 37432742. Download PDF
Maarsingh H, Oldenburger A, Han B, Zuidhof AB, Elzinga CRS, Timens W, Meurs H, Sopi RB, Schmidt M. Effects of (a Combination of) the Beta<sub>2</sub>-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction. Cells. 2021 May 18;10(5):1237. PMID: 34069899; PMCID: PMC8157597. Download PDF
van den Berg M, Nijboer-Brinksma S, Bos S, van den Berge M, Lamb D, van Faassen M, Kema I, Gosens R, Kistemaker L. Withdrawn: The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs. Br J Pharmacol. 2020 Oct;177(20):4809. PMID: 32436213; PMCID: PMC7520438. Download PDF
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