The intestines are part of the digestive system that runs from the stomach to the anus, responsible for nutrient absorption and waste elimination. They play a crucial role in maintaining overall health and well-being, and any dysfunction can lead to serious health problems. Tissue sections are needed to study the intestines as they provide a thin and flat sample that can be easily sliced and observed under a microscope. This allows researchers to investigate the cellular and molecular mechanisms underlying various intestinal functions, such as nutrient absorption, immune response, and microbiota interactions, and to identify changes that occur in intestinal diseases and disorders, such as inflammatory bowel disease and colorectal cancer.
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Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH. In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun. 2021 Jul 13;12(1):4291. PMID: 34257302; PMCID: PMC8277817. Download PDF
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