Humans are sometimes used as an animal model in research, particularly in clinical trials. Clinical trials involve testing new drugs, treatments, or medical devices on human subjects to determine their safety and effectiveness. These trials may focus on a wide range of diseases and conditions, including cancer, cardiovascular disease, infectious diseases, neurological disorders, and more.
To section large or entire specimens of human brain, the Compresstome® VF-800-0Z and is the vibrating microtome models designed for larger tissue samples. Rather than using the freeze-thaw technique common for cryostats, the Compresstome® allows fresh and fixed tissues to be cut directly without freezing.
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Often heralded as leaders in the field, the Allen Brain institute performs pioneering research on all manner of brain tissue. Working with brain tissue can often be as frustrating as it is rewarding. Slicing brain tissue presents many challenges. The tissue is a combination of soft and fibrous regions. For over a decade, researchers at the Allen Institute for Brain Science have been using the Compresstome® vibrating microtome to help give them better brain slices with increased longevity and reduced damage to surface neurons. This enables neuroscientists to have healthy neurons for patch-clamp electrophysiology experiments.
Dr. Travascio described the key functions, structures and composition of the meniscus in the knee and explained experimental methods for characterizing tissue transport and mechanical properties for the meniscus.
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