Large sample (whole organ) sectioning

Large sample sectioning refers to the process of cutting sections of an entire organ or tissue rather than small fragments. It is important because it allows researchers to study the tissue architecture, distribution of cells, and organization of cells and their components in three dimensions. This technique is commonly used in research to study the development of tumors, investigate the effects of diseases on organs, and develop new treatments for various conditions.

Recommended Models

VF-800-0Z

Compresstome vibrating microtome

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References

Xu F, Shen Y, Ding L, Yang CY, Tan H, Wang H, Zhu Q, Xu R, Wu F, Xiao Y, Xu C, Li Q, Su P, Zhang LI, Dong HW, Desimone R, Xu F, Hu X, Lau PM, Bi GQ. High- throughput mapping of a whole rhesus monkey brain at micrometer resolution. Nat Biotechnol. 2021 Dec;39(12):1521-1528. doi: 10.1038/s41587-021-00986-5. Epub 2021 Jul 26. PMID: 34312500. Download PDF

Pesce L, Scardigli M, Gavryusev V, Laurino A, Mazzamuto G, Brady N, Sancataldo G, Silvestri L, Destrieux C, Hof PR, Costantini I, Pavone FS. 3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy. Commun Biol. 2022 May 12;5(1):447. doi: 10.1038/s42003-022-03390-0. PMID: 35551498; PMCID: PMC9098858. Download PDF

Yu W, Kang L, Tsang VTC, Zhang Y, Wong IHM, Wong TTW. Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining. Elife. 2022 Nov 4;11:e81015. doi: 10.7554/eLife.81015. PMID: 36331195; PMCID: PMC9671503. Download PDF