The liver is a large organ that plays a crucial role in metabolism, detoxification, and protein synthesis. It is responsible for filtering toxins and waste products from the blood, producing bile to aid in digestion, and regulating glucose and lipid metabolism. Tissue sections are needed to study the liver as they provide a thin and flat sample that can be easily sliced and observed under a microscope. This allows researchers to investigate the cellular and molecular mechanisms underlying various liver functions, such as hepatocyte metabolism, liver regeneration, and immune response, and to identify changes that occur in liver diseases and disorders, such as hepatitis, cirrhosis, and liver cancer.
Not sure which model is right for your needs?
Visikol is a contract research services company focused on leveraging advanced imaging, 3D cell culture assays and digital pathology to accelerate the drug discovery and development process. In this webinar, Visikol explains the need for in vitro liver models to study livery injury. They demonstrate the standard assay format for creating precision-cut liver slices (PCLS), and explain how the Compresstome® VF-310-0Z vibrating microtome helps create uniform tissue slices that can be meaningfully compared between treatments. Visikol goes through how to use the Compresstome® step-by-step for making PCLS.
Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022 Feb 8;55(2):254-271.e7. PMID: 35139352; PMCID: PMC8852844. Download PDF
Liu P, Anandhan A, Chen J, Shakya A, Dodson M, Ooi A, Chapman E, White E, Garcia JG, Zhang DD. Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biol. 2023 Feb;59:102570. Epub 2022 Dec 5. PMID: 36495698; PMCID: PMC9731892. Download PDF
Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 Mar;603(7902):736-742. Epub 2022 Mar 9. PMID: 35264794; PMCID: PMC9014868. Download PDF
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