Advantages of the Compresstome®

  • Reduced structural damage: Tissue stabilization preserves structural integrity and details.
  • Smooth sections: tissue stabilization = No artifacts
  • Easy to maintain: Auto-Zero-Z means Zero-Z with no calibration needed.
  • Easy to learn: Many labs get great smooth slices on first or second try with the Compresstome.

Problems with traditional vibrating microtomes

  • Structural damage: Tissue tearing, folding, and shredding would compromise structural integrity.
  • Slice thickness variability: Inconsistent thickness can affect the repeatability of experiments.
  • Maintenance and calibration: Need time consuming maintenance requiring specialized knowledge or could lead to degrading performance.
  • Steep learning curve: Requires A LOT of practice to perfect, particularly for users who are new to IHC and tissue preparation.

Softer materials (biogel, scaffolding, tissue matrix, etc.):

Softer materials such as biogel, tissue matrix, organoids, can be sectioned easily with the Compresstome. Applications such as

  • Matrix & scaffolding sectioning for tissue bioengineering

See why the Compresstome is better.

Harder Tissues (hard plastic, bone etc.):

Hard materials can be sectioned easily with the Precisionary microtomes. Applications such as

  • Polymer sectioning for mechanical and materials science engineering
  • Paint defect analysis (injection molding with primers and paints) in the automotive industry
  • Hard materials including bone for biology and histopathology research

Precisionary Microtomes

  • Durability: Durable build with an industry leading 3 year warranty
  • Full Product line: available in automatic, semi-automatic, and manual (links for all) models
  • Easy to own: Solid supply chain and repair channels to ensure availability for your purchase and your maintenance.
  • Turnkey solution: All you need to get started comes with your microtome, so you can hit the ground running.

Recommended Models

Not sure which model is right for your needs?

Real lab examples

Play Video

Characterization of Biomechanical and Biotransport Properties of Meniscus: Investigating Their Relationships with Tissue Structure and Composition

Dr. Travascio described the key functions, structures and composition of the meniscus in the knee and explained experimental methods for characterizing tissue transport and mechanical properties for the meniscus.


Wang WY, Kent RN 3rd, Huang SA, Jarman EH, Shikanov EH, Davidson CD, Hiraki HL, Lin D, Wall MA, Matera DL, Shin JW, Polacheck WJ, Shikanov A, Baker BM. Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter. Acta Biomater. 2021 Nov;135:260-273. Epub 2021 Aug 29. PMID: 34469789; PMCID: PMC8595798. Download PDF

Zhou Y, Pereira G, Tang Y, James M, Zhang M. 3D Porous Scaffold-Based High-Throughput Platform for Cancer Drug Screening. Pharmaceutics. 2023 Jun 9;15(6):1691. PMID: 37376138; PMCID: PMC10304563. Download PDF

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