With our patented compression technology, The Compresstome® overcomes these issues and can produce slices that have

  • More Live cells: Compression stabilizes the tissue, producing much more living cells on live tissues.
  • Smooth sections: tissue stabilization + Auto-Zero-Z® = No artifacts

Muscle tissues have the following characteristics that makes it difficult for traditional Vibratomes to section

  • Variability in tissue texture: Different types of muscle tissue, such as skeletal, cardiac, and smooth muscle, can have different textures and densities. This variability can make it challenging to produce uniform sections with a vibratome, and dense regions may cause the blade to skip or produce uneven section thickness.
  • Presence of delicate structures: Muscle tissue contains several delicate structures, such as blood vessels, nerves, and muscle fibers, that can be easily damaged during sectioning. The vibratome blade may tear or crumple these structures, leading to unusable or distorted sections.

Recommended Models

VF-510-0Z

Compresstome vibrating microtome

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References

Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH. In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun. 2021 Jul 13;12(1):4291. PMID: 34257302; PMCID: PMC8277817. Download PDF

Chung DJ, Madison GP, Aponte AM, Singh K, Li Y, Pirooznia M, Bleck CKE, Darmani NA, Balaban RS. Metabolic design in a mammalian model of extreme metabolism, the North American least shrew (Cryptotis parva). J Physiol. 2022 Feb;600(3):547-567. Epub 2021 Dec 13. PMID: 34837710. Download PDF

Liu Y, Lv L, Wang L, Zhong Y. Social Isolation Induces Rac1-Dependent Forgetting of Social Memory. Cell Rep. 2018 Oct 9;25(2):288-295.e3. PMID: 30304669. Download PDF

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