With our patented compression technology, The Compresstome® overcomes these issues and can produce slices that have

  • More Live cells: Compression stabilizes the tissue, producing much more living cells on live tissues.
  • Smooth sections: tissue stabilization + Auto-Zero-Z® = No artifacts

Reproductive Organ tissues have the following characteristics that makes it difficult for traditional Vibratomes to section

  • Variability in tissue density: Reproductive tissues, such as the testes or ovaries, contain several different types of tissue with varying densities. This variability can make it challenging to produce uniform sections with a vibratome, and dense regions may cause the blade to skip or produce uneven section thickness.
  • Presence of delicate structures: Reproductive tissues contain several delicate structures, such as blood vessels, ducts, and germ cells, that can be easily damaged during sectioning. The vibratome blade may tear or crumple these structures, leading to unusable or distorted sections.

Recommended Models

VF-510-0Z

Compresstome vibrating microtome

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References

Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022 Feb 8;55(2):254-271.e7. PMID: 35139352; PMCID: PMC8852844. Download PDF

Siewiera J, McIntyre TI, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A. Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity. Immunity. 2023 Mar 14;56(3):606-619.e7. Epub 2023 Feb 6. PMID: 36750100; PMCID: PMC10023352. Download PDF

Vitek RA, Huang W, Geiger PG, Heninger E, Lang JM, Jarrard DF, Beebe DJ, Johnson BP. Fresh tissue procurement and preparation for multicompartment and multimodal analysis of the prostate tumor microenvironment. Prostate. 2022 May;82(7):836-849. Epub 2022 Feb 28. PMID: 35226381; PMCID: PMC9010374. Download PDF

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