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With our patented compression technology, The Compresstome® overcomes these issues and can produce slices that have

  • More Live cells: Compression stabilizes the tissue, producing much more living cells on live tissues.
  • Smooth sections: tissue stabilization + Auto-Zero-Z® = No artifacts
  • Easy to orient: The agarose embedding method and specimen tube support provides a easy way to orient the flimsy tissue for sectioning.

Spinal Cord tissues have the following characteristics that makes it difficult for traditional Vibratomes to section

  • Variability in tissue texture: The spinal cord contains several different types of neural tissue, such as white matter, gray matter, and nuclei, each with different textures and densities. This variability can make it challenging to produce uniform sections with a vibratome, and dense regions may cause the blade to skip or produce uneven section thickness.
  • Presence of delicate structures: The spinal cord contains several delicate structures, such as the meninges, blood vessels, and neural fibers, that can be easily damaged during sectioning. The vibratome blade may tear or crumple these structures, leading to unusable or distorted sections.
  • Soft and pliable tissue: The soft and pliable nature of spinal cord tissue can make sectioning challenging

Recommended Models


Compresstome vibrating microtome

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Real lab examples


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Tsujikawa S, DeMeulenaere KE, Centeno MV, Ghazisaeidi S, Martin ME, Tapies MR, Maneshi MM, Yamashita M, Stauderman KA, Apkarian AV, Salter MW, Prakriya M. Regulation of neuropathic pain by microglial Orai1 channels. Sci Adv. 2023 Jan 27;9(4):eade7002. Epub 2023 Jan 27. PMID: 36706180; PMCID: PMC9883051. Download PDF

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