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With our patented compression technology, The Compresstome® overcomes these issues and can produce slices that have

  • More Live cells: Compression stabilizes the tissue, producing much more living cells on live tissues.
  • Smooth sections: tissue stabilization + Auto-Zero-Z® = No artifacts
  • Easy to orient: The agarose embedding method and specimen tube support provides a easy way to orient the flimsy tissue for sectioning.

Spinal Cord tissues have the following characteristics that makes it difficult for traditional Vibratomes to section

  • Variability in tissue texture: The spinal cord contains several different types of neural tissue, such as white matter, gray matter, and nuclei, each with different textures and densities. This variability can make it challenging to produce uniform sections with a vibratome, and dense regions may cause the blade to skip or produce uneven section thickness.
  • Presence of delicate structures: The spinal cord contains several delicate structures, such as the meninges, blood vessels, and neural fibers, that can be easily damaged during sectioning. The vibratome blade may tear or crumple these structures, leading to unusable or distorted sections.
  • Soft and pliable tissue: The soft and pliable nature of spinal cord tissue can make sectioning challenging

Recommended Models

VF-510-0Z

Compresstome vibrating microtome

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Not sure which model is right for your needs?

Real lab examples

References

Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT. h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex. Neuron. 2018 Dec 5;100(5):1194-1208.e5. Epub 2018 Nov 1. PMID: 30392798; PMCID: PMC6447369. Download PDF

Navickaite I, Pauziene N, Pauza DH. Anatomical evidence of non- parasympathetic cardiac nitrergic nerve fibres in rat. J Anat. 2021 Jan;238(1):20-35. Epub 2020 Aug 13. PMID: 32790077; PMCID: PMC7755078. Download PDF

Tsujikawa S, DeMeulenaere KE, Centeno MV, Ghazisaeidi S, Martin ME, Tapies MR, Maneshi MM, Yamashita M, Stauderman KA, Apkarian AV, Salter MW, Prakriya M. Regulation of neuropathic pain by microglial Orai1 channels. Sci Adv. 2023 Jan 27;9(4):eade7002. Epub 2023 Jan 27. PMID: 36706180; PMCID: PMC9883051. Download PDF

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