With our patented compression technology, The Compresstome® overcomes these issues and can produce slices that have

  • Smooth sections: tissue stabilization = No artifacts
  • Minimal tissue damage: Tissue stabilization preserves cellular level structural integrity and details.

Cancer tumors have the following characteristics that makes it difficult to traditional Vibratomes to section

  • Heterogeneous composition: Tumor tissues have a diverse mix of cell types, densities, and structures that make it difficult to produce uniform sections with a vibratome.
  • Softness and fragility: Tumor tissues can be softer and more fragile than normal tissues, which can lead to damage and affect the quality of the sections.
  • Necrosis and hemorrhage: The presence of necrosis or hemorrhage in tumor tissues can alter the tissue structure and composition, making it challenging to produce accurate sections.

Recommended Models

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Real lab examples

Using the Compresstome® in Immunotherapy Research

Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.

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Slicing up the tumor: Lessons from attempted lung tumor slice cultures

Dr. Tsilingiri is working on tumor immunotherapy and using the Compresstome vibrating microtome to examine the interaction between tumor tissues and autologous lymph node cells in slice cultures. This work is being carried out in the frame of an EU-funded Consortium, Tumour-LNoC (Tumour-Lymph node on a chip), with the ultimate goal of mimicking the metastatic process on a chip and monitor metastasizing cells in real time.

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From two-dimensional to three-dimensional histopathology using a Compresstome®

Dr. Wong shares how he built a custom-made Compresstome® for high-speed histological 3D imaging of whole organs like brains.

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Tumor Slice Organoids for Cancer Precision Therapy

In this webinar, Dr. Dong will:

  • Discuss how cancer treatment decisions are made largely based on clinical guidelines
  • Explain how tumor slice organoids are a promising approach for delivering precise cancer therapy through biomarker search and phenotypic cancer drug susceptibility testing
  • Explore how rapid processing of tumor specimen into sliced organoids is important in preserving morphological and molecular fidelity

References

Donelan W, Crispen PL, Kusmartsev S. Tissue Slice Culture and Analysis of Tumor-Associated Hyaluronan in Urothelial Carcinoma. Methods Mol Biol. 2023;2684:167-175. PMID: 37410234. Download PDF

Nickl V, Eck J, Goedert N, Hübner J, Nerreter T, Hagemann C, Ernestus RI, Schulz T, Nickl RC, Keßler AF, Löhr M, Rosenwald A, Breun M, Monoranu CM. Characterization and Optimization of the Tumor Microenvironment in Patient- Derived Organotypic Slices and Organoid Models of Glioblastoma. Cancers (Basel). 2023 May 10;15(10):2698. doi: 10.3390/cancers15102698. PMID: 37345035; PMCID: PMC10216617. Download PDF

Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O’Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T. Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA-Associated Pancreatic Cancer in the Clinical and Preclinical Setting. Cancer Discov. 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843; PMCID: PMC10401074. Download PDF

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