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Webinars > Investigating how sodium channels regulate the firing of cerebellar Purkinje neurons requires healthy brain slices

Investigating how sodium channels regulate the firing of cerebellar Purkinje neurons requires healthy brain slices

Original webinar date: November 15, 2023
Guest name: Joseph L. Ransdell, PhD​

Dr. Joseph Ransdell completed his undergraduate degree in Neuroscience at the University of Minnesota. He then completed his Ph.D. at the University of Missouri Columbia and studied the regulation of membrane excitability in crab motor neurons. After receiving his Ph.D., he joined the lab of Jeanne Nerbonne at Washington University. There, he continued using electrophysiological methods to test how ion channel accessory proteins regulate the excitability of various types of mouse central neurons. In 2020, Dr. Ransdell started his independent lab at Miami University in Oxford, OH. He continues to work with mouse models and his team has centered their focus on the regulation of voltage-gated sodium channels and the contributions of the channels to the functioning of cerebellar circuits during health and disease.

In this webinar, Dr. Ransdell explores how the Compresstome vibrating microtome is used to produce healthy brain slices for electrophysiology. He studies adult Purkinje neurons in mouse cerebellar brain slices.

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