Webinars > Investigating lung development and regeneration using precision-cut lung slice (PCLS) models

Investigating lung development and regeneration using precision-cut lung slice (PCLS) models

Original webinar date: February 6, 2024
Guest name: Charlotte Dean, PhD

Dr. Dean leads a research group at Imperial College London’s National Heart and Lung Institute, specializing in lung development and repair. Their mission is to leverage the similarities between lung development and disease to gain insights into lung disease pathobiology and pioneer innovative regenerative and repair strategies. Their research explores the potential of regenerative biology to restore damaged lungs, particularly in cases where repair is hindered by genetic mutations or repeated exposure to pollutants or smoking. Dr. Dean’s work centers on alveolar biology and involves the development of cutting-edge tools, including precision-cut lung slices, to advance the study of post-natal lung development and mechanisms of repair, which will be discussed in the upcoming webinar.

In this webinar, Dr. Dean will:

  • Summarize the significance of live imaging of lung slices in elucidating the processes involved in lung development.
  • Explain the key principles and components of the acid-injury and repair model, demonstrating an understanding of its relevance in studying lung repair and regeneration.
  • Demonstrate the process of achieving recombination of floxed alleles in lung slices ex-vivo, applying the techniques and methods discussed during the webinar.
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