- Patented compression technology and agarose embedding process stabilizes tissue and eliminates chattermarks
- Slices over 5x faster than other market Vibrating Microtome
- Preserves surface neurons yielding over 2x healthy/dead cell ratios and significantly improving patch clamping results for electrophysiology
- Slice thickness ranging from 4 μm-2000μm
- No freezing needed! Allowing for free floating staining for better IHC – lmmunohistochemistry results
- Fully automated slicing, so no more tedious cryostat cranking
- Auto Zero-Z® technology reduces z-axis deflection to <1 μm
- Light footprint for increased portability
Benefits of Compression
When using the Compresstome®, you will embed your tissue in agarose inside a specimen tube. The open end of the specimen tube has a slightly tapered edge. As tissue and agarose cross the edge of the tube, it gets slightly squeezed thus uniformly compressing the tissue within. This compression helps stabilize the tissue during sectioning, and allows the Compresstome® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome® provides a significant improvement on the health and longevity of live slices, and virtually eliminate chattermarks in fixed tissue slices.
Above you can see the significant reduction in chattermarks between our Compresstome® VF-300-0Z and another leading market vibrating microtome.
- More than doubles the ratio of healthy-to-dead cells of acutely cut brain slices by preserving the upper surface layers of neurons.
- Preserves subcellular microstructure by stabilizing tissue samples during sectioning.
- Dramatically increases brain slice survival time from an average of 12 hours for other market vibrating microtomes up to 36 to 48 hours in ACSF!
- The Compresstome® is ideal for getting healthy neurons for patch-clamp recording from mature mice (over 18+ months!). Check out www.brainslicemethods.com
Compresstome® slicer models marked with “-0Z” mean that the model has our patented Auto Zero-Z® technology. These vibrating heads are precisely aligned to eliminate vibrations in the Z-axis need to be calibrated for each cut. These improvements save you time and money in the lab. Auto Zero-Z technology helps reduce damage to surface cells on live tissue samples, and further reduce chattermarks on thin sections for improved imaging results.
HOW CAN THE COMPRESSTOME® HELP YOU?
Search by Experiment
Search by Tissue Type
Search by Animal Model