Makers of the Compresstome®

Introducing the NEW Compresstome® VF-310-0Z

We have exciting news at Precisionary Instruments! We are launching the new Compresstome VF-310-0Z vibrating microtome model and here’s why we think you’ll love it:

  • Easier to use
  • Easier to clean
  • More control features
  • Better durability
  • Same high quality slices with Auto-Zero Z technology


  • Patented compression technology and agarose embedding process stabilizes tissue and eliminates chattermarks
  • Slices over 5x faster than other market Vibrating Microtome
  • Preserves surface neurons yielding over 2x healthy/dead cell ratios and significantly improving patch clamping results for electrophysiology
  • Slice thickness ranging from 4 μm-2000μm
  • No freezing needed! Allowing for free floating staining for better IHC – lmmunohistochemistry results
  • Fully automated slicing, so no more tedious cryostat cranking
  • Auto Zero-Z® technology reduces z-axis deflection to <1 μm
  • Light footprint for increased portability


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Compresstome® VF-310-0Z

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Compresstome® VF-300-0Z

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Compresstome® VF-200-0Z

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“Currently, we are able to routinely perform (on a daily basis) patch-clamp recordings from mechanically-dissociated neurons with adherent boutons only when using the VF-200, which was previously unobtainable using vibrating microtomes purchased from other leading companies.”

-Dr. Jie Wu, Director of Epilepsy Research, Barrow Neurological Institute

“The main advantages of this machine are the rapid speed of slicing and the manual stabilization afforded by the agarose embedding. I am able to prepare uniform slices in both the coronal and horizontal planes, and I routinely complete transcardial perfusion, brain removal, and slicing all within less than 10 minutes, which is half the time needed with the Vibrating microtome model.”

-Dr. Jonathan Ting, Allen Institute

“[W]e have experience using a variety of microtomes from different vendors, [but] we were excited by the VF-300’s ability to provide superior slices.”

-Dr. Yan Gu and Dr. Shaoyu Ge, Department of Neurobiology, SUNY at Stony Brook

“I have been consistently cutting exceptional quality brain slices and have succeeded in obtaining stable whole-cell patch recordings from numerous neurons.”

-Dr. Newton Woo, PhD NICHD/NIH

“Immediately we experienced success in obtaining mechanically-dissociated neurons with adherent pre-synaptic boutons using the microtome from Precisionary Instruments, Inc., and we also noticed [that the] cell quality was much higher when compared to neurons obtained using the other vibrating microtomes”.

-Dr. Jie Wu, Director of Epilepsy Research, BarrowNeurological Institute

“When I use the VF-200, I have a significantlygreater number of surface neurons than those slices cut from a regular Vibrating microtome. In addition the slice surface is much more even, which allows for better imaging.”

-Dr. Newton Woo, PhD NICHD/NIH

“We obtained surprisingly good electrophysiology results from even slices of relatively old (6 week) animals. The slices were very clean on the surface, and the majority of the cells were alive including those very close to the surface.”

-Dr. Yan Gu and Dr. Shaoyu Ge, Department of Neurobiology, SUNY at Stony Brook

“I am thoroughly impressed with the VF-200 and would not hesitate recommending this quality product to fellow electrophysiologists.”

-Dr. Newton Woo, PhD NICHD/NIH

“We found the Compresstome produces a less apparent damage to the cells of the airways and arterioles as well as to the delicate alveolar parenchyma. Using the Compresstome we are able to obtain more reproducible and successful experiments.”

-Dr. Perez-Zoghbi, Texas Tech University

“With the Compresstome® I was able to prepare high quality slices with excellent preservation near the slice surface.”

-Dr. Jonathan Ting, Allen Institute

“[T]he model’s design is also suited for cutting small or very soft tissues. We also used it for preparing organotypic tissue cultures, and it worked well.”

-Dr. Yan Gu and Dr. Shaoyu Ge, Department of Neurobiology, SUNY at Stony Brook

“I have successfully been able to do targeted whole-cell recordings from fluorescently labeled neurons in slices prepared from >1 year old mice, which is not generally possible with conventional slicers and methods.”

-Dr. Jonathan Ting, Allen Institute

“[C]ell survival rates were significantly higher when using the VF-200.”

-Dr. Jie Wu, Director of Epilepsy Research, Barrow Neurological Institute

“The VF-300 is more consistent in generating uniform slices and leaves the structure of the tissue/cells more intact than the method we had been using. We have been able to extend the amount of time over which we can cut lung slices, and allows preservation of the architecture of the slice and greater viability of the tissue.”

-Dr. Cynthia Kozial-White, University of Pennsylvania