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APPLICATIONS | EXPERIMENTS

Tissue Sectioning Solutions for Imaging Systems

Obtain consistent tissue sections crucial for fluorescence microscopy, calcium imaging, and more with Precisionary Instruments’ vibratomes, microtomes, and cryostats.

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Example Qijun Tang

Get Consistent Tissue Sections for Fluorescence Microscopy and Calcium Imaging

For techniques like fluorescence microscopy and calcium imaging, tissue sections must have smooth surfaces to prevent artifacts that could obscure critical data. Any imperfections, such as chattermarks, can distort imaging results. Precisionary Instruments’ vibratomes, microtomes, and cryostats deliver consistent, smooth tissue sections, ensuring fast, reliable results for a variety of imaging applications.

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Compresstome® VF-510-0Z

Vibrating Microtome for Live Tissue Sections in Imaging

The Compresstome® VF-510-0Z is perfect for producing live tissue slices for imaging applications such as calcium imaging and fluorescence microscopy. This fully automated system ensures smooth tissue surfaces, preventing artifacts that can obscure critical imaging data. Experimental applications include:

  • Live tissue sectioning for calcium imaging
  • Consistent, smooth slices for fluorescence microscopy
  • Artifact-free sectioning for high-quality imaging

With a 5-year warranty, the VF-510-0Z guarantees reliable and precise tissue sectioning for a variety of live tissue imaging techniques.

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Rotary Microtome RF-1000

Automated Microtome for Fluorescence Microscopy and Imaging

The RF-1000 rotary microtome is ideal for producing ultra-thin tissue sections with smooth surfaces, essential for fluorescence imaging of stained tissues. This fully automated system ensures consistent results, preventing imaging distortions caused by imperfections in the tissue. Experimental applications include:

  • Tissue sectioning for fluorescence microscopy
  • Smooth, consistent slices for imaging without artifacts
  • Reliable sections for high-resolution imaging of stained tissues

With a 3-year warranty, the RF-1000 delivers precision and reliability for imaging-based research.

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Cryostat CF-6100

Cryostat for Frozen Sectioning in Imaging

The Precisionary Cryostat CF-6100 is designed to produce smooth, consistent frozen tissue sections, ideal for imaging applications such as fluorescence microscopy. Its automated features ensure reproducibility while preserving tissue integrity for artifact-free imaging. Experimental applications include:

  • Frozen tissue sectioning for fluorescence microscopy
  • Smooth, consistent slices for high-quality imaging of stained tissues
  • Preservation of sample structure for imaging accuracy

Acting as a laboratory workhorse, the CF-6100 offers reliable frozen sectioning for imaging applications for years to come.

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TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Imaging

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for imaging, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

  • Intuitive controls
  • Fully programmable ON/OFF control allows automatic system start and stop.
  • Large drain holes that allow easy drainage into trays under all working areas
  • Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
  • Simple maintenance and repair in case of a malfunction

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Real Labs Trust Precisionary Vibratomes for Their Tissue Imaging Applications

Using the Compresstome® in Immunotherapy Research

Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.

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Making Precision-Cut Tissue Slices for Ex Vivo Assay Services

Visikol is a contract research services company focused on leveraging advanced imaging, 3D cell culture assays and digital pathology to accelerate the drug discovery and development process. In this webinar, Visikol explains the need for in vitro liver models to study livery injury. They demonstrate the standard assay format for creating precision-cut liver slices (PCLS), and explain how the Compresstome® VF-310-0Z vibrating microtome helps create uniform tissue slices that can be meaningfully compared between treatments. Visikol goes through how to use the Compresstome® step-by-step for making PCLS.

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A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

This footage shows how neuroscientists use the Compresstome® tissue slicer to obtain brain slices for imaging studies. When using the Compresstome®, tissue is embedded inside one of the specimen tubes. The specimen tube is made of two pieces: the inner plastic plunger and the outer metal tube. The inner plastic plunger is where you will mount your sample. The plunger is drawn down for your tissue sample to be embedded inside the metal tube. Please visit our website to learn more about our unique tissue slicers.

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Slicing up the tumor: Lessons from attempted lung tumor slice cultures

Dr. Tsilingiri is working on tumor immunotherapy and using the Compresstome vibrating microtome to examine the interaction between tumor tissues and autologous lymph node cells in slice cultures. This work is being carried out in the frame of an EU-funded Consortium, Tumour-LNoC (Tumour-Lymph node on a chip), with the ultimate goal of mimicking the metastatic process on a chip and monitor metastasizing cells in real-time.

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Advancing 3D Histopathology with a Custom-Made Compresstome®

Dr. Terence Tsz Wai Wong, Director of the HKUST Research Center for Medical Imaging and Analysis, developed a custom-made Compresstome® for high-speed, three-dimensional histological imaging of whole organs. In this webinar, Dr. Wong demonstrates how this innovative tool is transforming imaging techniques, enabling detailed 3D analysis of tissues like the brain and advancing medical imaging research.

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Lab Spotlight: Dr. Lingyan Shi and the Optical Bioimaging and Spectroscopy Lab at UC San Diego

Dr. Lingyan Shi leads the Laboratory of Optical Bioimaging and Spectroscopy at UC San Diego, where her team uses advanced imaging techniques to study cellular metabolism in real time. Their innovative work focuses on combining optical bioimaging and spectroscopy to enhance disease detection and provide new insights into metabolic processes.

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Compresstome® Vibratome Supports McMahon Lab Neuroscience Projects

Dr. McMahon and Dr. Jordan Logue’s team at MUSC utilize the Compresstome® vibratome to enhance tissue preparation for their neuroscience research. This precision instrument allows them to obtain high-quality brain slices, particularly from difficult-to-access regions like the locus coeruleus (LC). The exceptional tissue preservation achieved with the Compresstome® enables detailed electrophysiology and immunohistochemistry studies, producing stunning visualizations of noradrenergic neurons and advancing our understanding of neuropsychiatric conditions.

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Imaging References

Koveal D, Rosen PC, Meyer DJ, Díaz-García CM, Wang Y, Cai LH, Chou PJ, Weitz DA, Yellen G. A high-throughput multiparameter screen for accelerated development and optimization of soluble genetically encoded fluorescent biosensors. Nat Commun. 2022 May 25;13(1):2919. PMID: 35614105; PMCID: PMC9133083.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 Mar;603(7902):736-742. Epub 2022 Mar 9. PMID: 35264794; PMCID: PMC9014868.

Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir. Immunity. 2023 Mar 14;56(3):576-591.e10. Epub 2023 Feb 22. PMID: 36822205. PMC9876792. 

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