Advantages of the Compresstome®

  • Minimal tissue damage: Compression stabilizes the lipid and various tissue types, holding the blood vessels in place, allowing a smooth section.
  • Smooth sections: tissue stabilization = No artifacts

Problems with traditional vibrating microtomes

  • High lipid content: Liver tissue contains a high amount of lipids, which can interfere with the vibratome cutting process and produce poor-quality sections. The lipids can cause the tissue to tear or smear, which can make it difficult to obtain usable sections.
  • Variability in tissue density: Liver tissue is composed of multiple cell types with different densities, which can make it challenging to produce uniform sections. The dense regions of the liver may cause the vibratome blade to skip or produce uneven section thickness.
  • Vascular structures: The liver is a highly vascular organ, which can make it difficult to obtain sections that are free of blood vessels. Blood vessels can cause the tissue to move during sectioning, leading to distorted or damaged sections.

Recommended Model/s

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Real lab examples

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Making Precision-Cut Tissue Slices for Ex Vivo Assay Services

Visikol is a contract research services company focused on leveraging advanced imaging, 3D cell culture assays and digital pathology to accelerate the drug discovery and development process. In this webinar, Visikol explains the need for in vitro liver models to study livery injury. They demonstrate the standard assay format for creating precision-cut liver slices (PCLS), and explain how the Compresstome® VF-310-0Z vibrating microtome helps create uniform tissue slices that can be meaningfully compared between treatments. Visikol goes through how to use the Compresstome® step-by-step for making PCLS.


Moen T, Torgersen J, Santi N, Davidson WS, Baranski M, Ødegård J, Kjøglum S,
Velle B, Kent M, Lubieniecki KP, Isdal E, Lien S. Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon. Genetics. 2015 Aug;200(4):1313-26. PMID: 26041276; PMCID: PMC4574245. Download PDF

Weidinger A, Dungel P, Perlinger M, Singer K, Ghebes C, Duvigneau JC, Müllebner A, Schäfer U, Redl H, Kozlov AV. Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators. Front Physiol. 2013 Jun 7
;4:138. PMID: 23760194; PMCID: PMC3675332 Download PDF

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