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APPLICATIONS | animals

Tissue Sectioning Solutions for Human Tissue Slicing

Create healthy, viable human tissue slices for clinical, preclinical, and biopsy analysis using Precisionary Instruments’ advanced sectioning tools.

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Get High-Quality Human Tissue Slices

Human tissue sectioning is essential for clinical trials, medical research, and biopsy analysis, where precise tissue slices provide critical insights into disease mechanisms, treatment efficacy, and patient outcomes. Sectioning human tissues, particularly large samples like liver lobes, lung lobes, or entire human brains, is a vital part of studying complex diseases, such as cancer, cardiovascular disorders, and neurological conditions.

Precisionary Instruments’ Compresstome VF-800-0Z offers unparalleled capability to accommodate large organ samples, making it an indispensable tool for transplant research and neuroanatomical studies. This unique capacity to section entire organs or large human tissue samples is not found elsewhere, ensuring researchers can achieve high-quality, consistent sections for advanced analysis in both clinical and research settings.

Human tissue slices produced using the Compresstome enable accurate histological analysis and facilitate critical research in drug screening, therapeutic development, and personalized medicine.

Compresstome VF-800-0Z Top Front
Compresstome VF-800-0Z Top Front Right
Compresstome VF-800-0Z Top Front Left
Compresstome VF-800-0Z Right Side
Compresstome VF-800-0Z Left Side
Compresstome VF-800-0Z Front
Compresstome VF-800-0Z Front Blade
Compresstome VF-800-0Z Controls
Compresstome VF-800-0Z Blade

Compresstome® VF-800-0Z

Precision Vibrating Microtome for Large Human Tissue Samples

The Compresstome® VF-800-0Z is specifically designed for sectioning large human tissue samples, including entire or partial organs such as liver lobes, lung lobes, and even entire human brains. This makes it ideal for transplant research and neuroanatomical studies. The VF-800-0Z enables researchers to section fresh or fixed tissues without freezing, preserving tissue integrity for precise pathology and clinical studies.

Experimental Applications Include:

  • Precision-cut human tissue sections for transplant research (e.g., liver and lung lobes)
  • Whole brain sections for neuroanatomical studies
  • Fresh or fixed human tissue sections for cancer, cardiovascular, and neurological research

With a 5-year warranty, the VF-800-0Z delivers reliable and precise sectioning for large human tissue samples, making it a key tool in clinical and research settings.

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Compresstome® VF-510-0Z

Ultra-Precise & Consistent Vibrating Microtome

Our VF-510-0Z Compresstome® tissue slicer is a top of the line vibrating microtome that can be used for all of your live or fixed tissue sectioning needs.
  • Great for live AND fixed tissues.
  • Consistent, high quality slices
  • Highly viable cells.

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RF 1000 Front Right Angle
RF 1000 Front Left Angle
RF 1000 Front
RF 1000 Specimen Clamp
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RF 1000 Knife Holder Set Knob
RF 1000 Knife Holder Cutting Stage
RF 1000 Foot Press
RF 1000 Cutting Stage Front
RF 1000 Cutting Stage Front Left

Rotary Microtome RF-1000

Fully Automated Microtome for Thin Human Tissue Sections

The RF-1000 rotary microtome provides exceptional precision in cutting thin, uniform sections from human tissues. This model is essential for histopathology and immunohistochemical studies, enabling researchers to analyze biopsy samples and human tissues with high-resolution imaging.

Experimental Applications Include:

  • Thin human tissue sections for immunohistochemistry
  • Consistent slices for microscopic imaging of human tissue structure
  • Reliable sectioning of paraffin-embedded human tissues for detailed histopathology

With a 3-year warranty, the RF-1000 delivers consistent and precise thin sectioning for human tissue studies, providing essential results in clinical research.

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Cryostat CF-6100

Cryostat for Frozen Sectioning of Human Tissue

The CF-6100 cryostat is designed for frozen sectioning of human tissues, ensuring that OCT-embedded biopsy and tissue samples remain intact during sectioning. This system is critical for preparing frozen sections used in immunohistochemistry, histopathology, and advanced imaging.

Experimental Applications Include:

  • Frozen biopsy samples for clinical and research applications
  • Consistent frozen tissue slices for cancer research and neurological studies
  • Reliable frozen sectioning for small and large human tissue samples

Acting as a laboratory workhorse, the CF-6100 ensures dependable frozen sectioning of human tissues for long-term research and clinical analysis.

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Paraffin Dispenser Cold plate
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Paraffin Dispenser foot pedal
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TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Human Tissue Slicing

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for human tissue slicing, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

  • Intuitive controls
  • Fully programmable ON/OFF control allows automatic system start and stop.
  • Large drain holes that allow easy drainage into trays under all working areas
  • Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
  • Simple maintenance and repair in case of a malfunction

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Real Labs Trust Precisionary Vibratome for Human Tissue Slicing

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Often heralded as leaders in the field, the Allen Brain institute performs pioneering research on all manner of brain tissue. Working with brain tissue can often be as frustrating as it is rewarding. Slicing brain tissue presents many challenges. The tissue is a combination of soft and fibrous regions. For over a decade, researchers at the Allen Institute for Brain Science have been using the Compresstome® vibrating microtome to help give them better brain slices with increased longevity and reduced damage to surface neurons. This enables neuroscientists to have healthy neurons for patch-clamp electrophysiology experiments.

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Characterization of Biomechanical and Biotransport Properties of Meniscus: Investigating Their Relationships with Tissue Structure and Composition

Dr. Travascio described the key functions, structures and composition of the meniscus in the knee and explained experimental methods for characterizing tissue transport and mechanical properties for the meniscus.

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References

Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nat Commun. 2023 Jun 8;14(1):3345. PMID: 37291094; PMCID: PMC10250345.

Driessens SLW, Galakhova AA, Heyer DB, Pieterse IJ, Wilbers R, Mertens EJ, Waleboer F, Heistek TS, Coenen L, Meijer JR, Idema S, de Witt Hamer PC, Noske DP, de Kock CPJ, Lee BR, Smith K, Ting JT, Lein ES, Mansvelder HD, Goriounova NA. Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types. Nat Commun. 2023 Jul 13;14(1):4188. PMID: 37443107; PMCID: PMC10345092.

Park TI, Smyth LCD, Aalderink M, Woolf ZR, Rustenhoven J, Lee K, Jansson D, Smith A, Feng S, Correia J, Heppner P, Schweder P, Mee E, Dragunow M. Routine culture and study of adult human brain cells from neurosurgical specimens. Nat Protoc. 2022 Feb;17(2):190-221. Epub 2022 Jan 12. PMID: 35022619.

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