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Human

Humans are sometimes used as an animal model in research, particularly in clinical trials. Clinical trials involve testing new drugs, treatments, or medical devices on human subjects to determine their safety and effectiveness. These trials may focus on a wide range of diseases and conditions, including cancer, cardiovascular disease, infectious diseases, neurological disorders, and more.

To section large or entire specimens of human brain, the Compresstome® VF-800-0Z and is the vibrating microtome models designed for larger tissue samples. Rather than using the freeze-thaw technique common for cryostats, the Compresstome® allows fresh and fixed tissues to be cut directly without freezing.

Recommended Model/s

VF-510-0Z

Compresstome vibrating microtome

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RF-1000

Rotary microtome

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Not sure which model is right for your needs?

Real lab examples

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Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Often heralded as leaders in the field, the Allen Brain institute performs pioneering research on all manner of brain tissue. Working with brain tissue can often be as frustrating as it is rewarding. Slicing brain tissue presents many challenges. The tissue is a combination of soft and fibrous regions. For over a decade, researchers at the Allen Institute for Brain Science have been using the Compresstome® vibrating microtome to help give them better brain slices with increased longevity and reduced damage to surface neurons. This enables neuroscientists to have healthy neurons for patch-clamp electrophysiology experiments.

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Characterization of Biomechanical and Biotransport Properties of Meniscus: Investigating Their Relationships with Tissue Structure and Composition

Dr. Travascio described the key functions, structures and composition of the meniscus in the knee and explained experimental methods for characterizing tissue transport and mechanical properties for the meniscus.

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References

Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ. Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. PMID: 27071111; PMCID: PMC4855555. Download PDF

Koziol-White CJ, Jia Y, Baltus GA, Cooper PR, Zaller DM, Crackower MA, Sirkowski EE, Smock S, Northrup AB, Himes BE, Alves SE, Panettieri RA Jr. Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices. Br J Pharmacol. 2016 Nov;173(21):3080-3087. PMID: 27417329; PMCID: PMC5056227. Download PDF

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016;1. pii: 0004. PMID: 28966873; PMCID: PMC5621647. Download PDF

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