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Precisionary Instruments offers a full line of high quality rotary microtomes for histopathology, research, and clinical purposes. Our microtomes give you reliable sections over a range of tissue slice thicknesses.
Histopathology is the study of disease by using a microscope to examine tissues or surgical biopsies that are processed, fixed, sectioned, and plated onto glass slides. Tissue slices are then processed by staining, where different dyes and antibodies help visualize specific components of tissues and proteins. Hematoxylin-Eosin (H&E) staining has been used in pathology for over a century.
Because histopathology requires extremely fine and thin tissue sections (often down to 5µm or thinner), obtaining consistent sections is crucial for further processing. The process of cutting tissue slices also needs to occur rapidly because serial sections are needed. Therefore, histology and pathology require a rotary microtome that can quickly make high quality thin tissue slices without friction, chattermarks, or inconsistencies.
Not sure which model is right for your needs?
Our rotary microtome RF-1000 is a fully automated microtome. Check out its keys features, and see it cutting specimen samples in this short video.
Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.
Explore how scientists use the Compresstome® vibrating microtome to create tissue slices that combine lipophilic dye tracing, whole mount in situ hybridization, immunohistochemistry, and histology to extract the maximal possible amount of data.
Dr. Tsilingiri is working on tumor immunotherapy and using the Compresstome vibrating microtome to examine the interaction between tumor tissues and autologous lymph node cells in slice cultures. This work is being carried out in the frame of an EU-funded Consortium, Tumour-LNoC (Tumour-Lymph node on a chip), with the ultimate goal of mimicking the metastatic process on a chip and monitor metastasizing cells in real time.
Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW. The mouse cortico-striatal projectome. Nat Neurosci. 2016 Aug;19(8):1100-14. PMID: 27322419. Download PDF
Mylvaganam GH, Rios D, Abdelaal HM, Iyer S, Tharp G, Mavinger M, Hicks S, Chahroudi A, Ahmed R, Bosinger SE, Williams IR, Skinner PJ, Velu V, Amara RR. Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1976-1981. PMID: 28159893; PMCID: PMC5338410. Download PDF
Wickersham IR, Sullivan HA, Seung HS. Axonal and subcellular labelling using modified rabies viral vectors. Nat Commun. 2013;4:2332. PMID: 23945836. Download PDF
Zingg B, Hintiryan H, Gou L, Song MY, Bay M, Bienkowski MS, Foster NN, Yamashita S, Bowman I, Toga AW, Dong HW. Neural networks of the mouse neocortex. Cell. 2014 Feb 27;156(5):1096-111. PMID: 24581503; PMCID: PMC4169118. Download PDF
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Phone: 617-682-0586
Fax: 1-866-424-2216
Compresstome Vibrating Microtomes
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Ordering guidelines
Warranty and service plans
Repair support
Experimental protocols
Partnerships and Distributors
Videos
User manuals
FAQs
Contact us
Video
User manuals
FAQs
Contact us
© 2023 copyright
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info@precisionary.com
Phone: 617-682-0586
Fax: 1-866-424-2216
© 2023 copyright
Privacy Policy