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APPLICATIONS | EXPERIMENTS

Tissue Sectioning Solutions for Immunohistochemistry

Produce high-quality tissue sections for immunohistochemistry with Precisionary Instruments’ vibratomes, microtomes, and cryostats.

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Get the Best Immunohistochemistry Results with Consistent Tissue Sections

Immunohistochemistry (IHC) is a powerful technique that uses antibodies to detect specific proteins or molecules within tissues, making it an essential tool in both research and clinical diagnostics. Accurate tissue sections are critical for this process, as they provide the thin, flat samples necessary for precise antibody staining and protein localization. Precisionary Instruments’ vibratomes, microtomes, and cryostats deliver the consistent, artifact-free sections required for IHC, allowing for clear identification of specific cells, tissues, and disease-related biomarkers. Our products ensure optimal sample preparation, helping you achieve reliable results in your immunohistochemistry studies.

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Compresstome® VF-510-0Z

Thin, Consistent Sections for Immunohistochemistry

The Compresstome® VF-510-0Z produces precise, thin tissue sections essential for immunohistochemistry (IHC) applications. Its fully automated system ensures flat, consistent slices, which are crucial for accurate antibody staining and analysis. Experimental applications include:

  • Thin sectioning for immunohistochemistry
  • Flat, consistent slices for antibody staining
  • Reliable sections for both research and clinical diagnostics

With a 5-year warranty, the VF-510-0Z ensures precision and reproducibility, making it ideal for IHC in various research and clinical settings.

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Cryostat CF-6100

Consistent, High-Quality Frozen Sections for Immunohistochemistry

The Precisionary Cryostat CF-6100 is designed for producing ultra-thin, frozen tissue sections required for immunohistochemistry (IHC). Its automated features ensure smooth, flat sections that are vital for high-quality antibody staining. Experimental applications include:

  • Frozen tissue sectioning for immunohistochemistry
  • Consistent, thin slices for accurate antibody staining
  • Preservation of tissue integrity for reliable IHC results

Acting as a laboratory workhorse, the CF-6100 ensures reliable frozen sectioning for immunohistochemistry applications over time.

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Rotary Microtome RF-1000

Thin, Artifact-Free Sections for Immunohistochemistry

The RF-1000 rotary microtome is perfect for producing ultra-thin, consistent sections required for antibody staining in immunohistochemistry (IHC). This fully automated system ensures smooth, flat sections, critical for high-quality staining and diagnostic analysis. Experimental applications include:

  • Thin tissue sections for immunohistochemistry
  • Consistent, flat slices for accurate antibody staining
  • Reliable sections for research and clinical IHC applications

With a 3-year warranty, the RF-1000 offers precision and reliability for immunohistochemistry tasks.

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Real Labs Trust Precisionary Vibratomes for Their Immunohistochemistry Experiments

“3D” use of animal tissues in experimental design

Have you wondered how one mouse brain may be used for multiple experiments? Come discover the strategy behind using animal tissues for multi-use research experiments, so that your tissue samples can go further. Dr. Yiying Zhang from Harvard Medical School and Massachusetts General Hospital is our guest webinar speaker. For this Precisionary webinar, Dr. Zhang will discuss a “3D” use of animal tissues in planning experimental designs in academic research.

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Using the Compresstome® in Immunotherapy Research

Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.

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Making Precision-Cut Tissue Slices for Ex Vivo Assay Services

Visikol is a contract research services company focused on leveraging advanced imaging, 3D cell culture assays and digital pathology to accelerate the drug discovery and development process. In this webinar, Visikol explains the need for in vitro liver models to study livery injury. They demonstrate the standard assay format for creating precision-cut liver slices (PCLS), and explain how the Compresstome® VF-310-0Z vibrating microtome helps create uniform tissue slices that can be meaningfully compared between treatments. Visikol goes through how to use the Compresstome® step-by-step for making PCLS.

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Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology

Explore how scientists use the Compresstome® vibrating microtome to create tissue slices that combine lipophilic dye tracing, whole mount in situ hybridization, immunohistochemistry, and histology to extract the maximal possible amount of data.

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In Situ MHC-tetramer Staining & Quantitative Analysis of Antigen-specific CD8 T Cells in Tissues

Fresh tissue can vary wildly in its level of difficulty to cut, due to a variety of factors like tissue type, and maturity of the animal (myelination). Often with other vibrating microtomes, they struggle to handle highly myelinated tissue or very soft neonatal tissue. The compression effect, along with multiple points of adjustment (speed, oscillation, and agarose concentration) enables our instrument to better handle “difficult” to cut tissue. 

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Slicing up the tumor: Lessons from attempted lung tumor slice cultures

Dr. Tsilingiri is working on tumor immunotherapy and using the Compresstome vibrating microtome to examine the interaction between tumor tissues and autologous lymph node cells in slice cultures. This work is being carried out in the frame of an EU-funded Consortium, Tumour-LNoC (Tumour-Lymph node on a chip), with the ultimate goal of mimicking the metastatic process on a chip and monitor metastasizing cells in real time.

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From two-dimensional to three-dimensional histopathology using a Compresstome®

Dr. Wong shares how he built a custom-made Compresstome® for high-speed histological 3D imaging of whole organs like brains.

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References

Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nat Commun. 2023 Jun 8;14(1):3345. PMID: 37291094; PMCID: PMC10250345.

Mastorakos P, Mihelson N, Luby M, Burks SR, Johnson K, Hsia AW, Witko J, Frank JA, Latour L, McGavern DB. Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury. Nat Neurosci. 2021 Feb;24(2):245-258. Epub 2021 Jan 18. PMID: 33462481; PMCID: PMC7854523.

Rindner DJ, Proddutur A, Lur G. Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex. Neuron. 2022 Nov 16;110(22):3760-3773.e5. Epub 2022 Sep 9. PMID: 36087582; PMCID: PMC9671855.

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