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The Tissue Sectioning Blog

Learn more about tissue sectioning from the experts at Precisionary Instruments. We cover all facets of tissue section including applications, best practices and advancements in the field.

Publication Highlight: How Alarmins Reshape Airway Tone in Human Small Airways

Key Takeaways IL-33 increased airway contraction and blunted the relaxation response to the rescue bronchodilator formoterol

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Fig. 2a from Riley et al. Medium spiny neuron somas imaged live in Compresstome-prepared acute tail striatum slices at 40x magnification.

Publication Highlight: Mapping the Electrophysiology of the Tail Striatum with Riley et al.

Key Takeaways The tail striatum (TS) is a poorly understood brain region linked to sensory processing,

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Publication Highlight: Psilocybin Prevents Chemotherapy-Induced Neuropathy by Preserving Mitochondrial Trafficking

Key Takeaways Two doses of psilocybin administered before chemotherapy prevented peripheral neuropathy in mice for up

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Publication Highlight: How Kv3.1 Channels Shape High-Frequency Firing in the Developing Auditory Brainstem

Key Takeaways Kv3.1b potassium channel expression increases substantially in the dorsal cochlear nucleus (DCN) of mice

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Publication Highlight: Mapping the Pacinian Corpuscle’s Touch-Sensing Architecture with the Compresstome

A new study from Yale University, published in Science Advances (Ziolkowski et al.), overturns a decades-old

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Publication Highlight: Synthetic Cooling Agents in E-Cigarettes Enhance Nicotine’s Addictive Grip on the Brain

Key Takeaways Synthetic cooling agents WS-3 and WS-23 — widely used as menthol substitutes in e-cigarettes

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Publication Highlight: Human Liver Tissue Viability Extended to 14 Days with the Compresstome Vibratome

Key Takeaways A new study from Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School,

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Advanced Techniques for Kidney Tissue Sectioning

From precision-cut slices to spatial multi-omics: how modern renal research cuts and reads kidney tissue Kidney

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Which Buffer Solution Should You Use? A Guide for Tissue Sectioning Applications

Formulas and rationale for live sectioning of brain, heart, lung, liver, organoids, and tumors There is

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Publication Highlight: Unmasking Treatment Vulnerabilities in a Rare Sinonasal Cancer Through Spatial Profiling and Ex Vivo Drug Testing

Key Takeaways Researchers profiled how SMARCB1-deficient sinonasal carcinoma responds to drugs directly in patient tumor tissue,

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Employee Spotlight: Matt Levin, VP of Sales

At Precisionary Instruments, our sales team is the first point of contact for the researchers, labs,

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Publication Highlight: Dr. Joannah Fergusson’s Breakthrough in Modeling Immune Responses Ex Vivo

At Precisionary Instruments, our ultimate goal is to support scientists throughout their careers and we absolutely

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