Publication Highlight: How Alarmins Reshape Airway Tone in Human Small Airways
Key Takeaways IL-33 increased airway contraction and blunted the relaxation response to the rescue bronchodilator formoterol in non-diseased human lung tissue, suggesting it can impair bronchodilator effectiveness independently of inflammation. IL-25 selectively increased airway contraction in asthma-derived tissue but had little effect in non-diseased tissue, pointing to a disease-specific vulnerability. TSLP did not significantly alter […]
