Artificial Cerebrospinal Fluid (ACSF) is an essential buffer solution widely used in electrophysiology experiments, particularly to keep acute brain slices alive during research. This solution closely mimics the natural cerebrospinal fluid found in the brain and is designed to maintain neuronal viability and function during experiments like patch-clamp recordings. In this article, we’ll explore the […]

In the realm of scientific research, particularly in histology, neuroscience, and pathology, precise sectioning of biological samples is critical. Two primary instruments used for this purpose are vibratomes and microtomes. Each has its unique advantages and applications, as well as some overlapping uses. In this article, we will explore the different experimental applications for vibratomes […]

If you’re involved in tissue sectioning, you’ve probably heard the terms “vibrating microtome” and “vibratome” thrown around quite a bit. Spoiler alert: they’re actually the same thing! But let’s dive a bit deeper into what these nifty tools are, their history, and how Precisionary Instruments has made some game-changing improvements over the years with our […]

Getting Started with Cardiac Slicing Welcome, fellow scientists, to a journey into the fascinating realm of cardiac tissue slicing! In the spirit of Valentine’s Day, where hearts take center stage as symbols of love and affection, let’s explore the intricate world of cardiac tissue and how precision slicing can unveil its mysteries. The History of Cardiac Slicing Our journey […]

The human brain, a complex network of billions of neurons, remains one of the greatest enigmas of science. In the quest to decode its mysteries, scientists have embarked on an ambitious endeavor called “projectomes.” Projectomes are comprehensive maps of the brain that detail the trajectories of individual long-distance projecting neurons, shedding light on how different […]

Compresstome Auto Zero-Z® Patented Technology The Compresstome® vibrating microtome lineup incorporates a significant technological advancement: our patented Auto Zero-Z® technology. This innovative feature is integral to Compresstome® models with names ending in “-0Z,” as it ensures meticulous alignment, eliminating oscillating deviations along the z-axis throughout the cutting process (Figure 1). Figure 1. Auto Zero-Z technology is equivalent to […]