Category: Publication Highlights
A new study from Yale University, published in Science Advances (Ziolkowski et al.), overturns a decades-old model of how the Pacinian corpuscle, the receptor responsible for detecting transient touch and high-frequency vibration in skin, actually works. Led by Elena Gracheva and Sviatoslav Bagriantsev, the team used the Compresstome to prepare tissue for high-resolution electron microscopy, […]
Written by Abby Chu on August 26, 2026
Key Takeaways Synthetic cooling agents WS-3 and WS-23 — widely used as menthol substitutes in e-cigarettes — significantly enhance nicotine self-administration behavior in mice, matching the reinforcing effects of menthol itself. These coolants boost dopamine release in the nucleus accumbens core, increase the excitability of dopamine neurons in the ventral tegmental area, and amplify nicotine-induced […]
Written by Abby Chu on August 17, 2026
Key Takeaways A new study from Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, generated with Precisionary’s Compresstome vibrating microtome, extends viable human precision-cut liver slice (PCLS) culture to 10 to 14 days, far beyond the field baseline where fewer than 7% of published PCLS studies maintain culture past 72 hours. During extended […]
Written by Abby Chu on August 5, 2026
Key Takeaways Researchers profiled how SMARCB1-deficient sinonasal carcinoma responds to drugs directly in patient tumor tissue, preserving the spatial architecture rather than dissociating the sample. Live tumor slices were generated on a Compresstome tissue slicer, producing uniform, viable sections suitable for ex vivo drug exposure. Drug responses varied across distinct regions of the same tumor, […]
Written by Abby Chu on July 27, 2026
At Precisionary Instruments, our ultimate goal is to support scientists throughout their careers and we absolutely love following them as they become successful in their respective fields. There is nothing more rewarding than partnering with brilliant minds, watching their projects evolve, and celebrating their monumental milestones. Today, we are thrilled to shine a Lab Spotlight […]
Written by Abby Chu on May 22, 2026
At Precisionary Instruments, we are committed to supporting cutting-edge research that advances our understanding of neurodegenerative diseases. In a recent study published in Communications Biology, Lo Cascio et al. (2025) explore the structure and properties of brain-derived tau oligomers, shedding light on their role in neurodegeneration. This research provides significant insights into how different tau […]
Written by Abby Chu on February 28, 2025
