Publication Highlight: How Hypercapnia Actively Drives Airway Constriction Through a STIM1-Dependent Calcium Signaling Axis
Key Takeaways Elevated CO2 (hypercapnia), common in advanced COPD, actively drives airway smooth muscle constriction rather than simply being a downstream symptom of disease severity. Hypercapnia activates ERK, which triggers calcium release and boosts STIM1 expression, amplifying calcium signaling that drives airway smooth muscle contraction. Precision-cut lung slices, prepared on a Compresstome tissue slicer, confirmed […]