Dr. Jian-young Wu is a Professor of Neuroscience at Georgetown University Medical Center, where he has led a research lab since 1995. He completed his PhD at Peking University in 1986, followed by postdoctoral training at Yale University from 1986 to 1993. Dr. Wu’s laboratory focuses on studying population neuronal activity—large-scale, coordinated firing patterns that underlie all brain functions and many neurological disorders. His work emphasizes the use of ex vivo hippocampal slices to investigate sharp wave activity, a critical form of network oscillation involved in memory consolidation and cognitive processing. These preparations offer an accessible and reproducible system for studying brain rhythms, disease mechanisms, and therapeutic drug candidates. Dr. Wu is also known for his hands-on approach to experimental neuroscience, mentoring students and tackling technical challenges at the bench.

In this webinar, Dr. Wu will:

– Explain the generation and significance of hippocampal sharp waves in ex vivo brain slices
– Share practical skills for preparing high-quality slices using the Compresstome® vibrating microtome
– Highlight examples of pharmacological agents that modulate sharp wave activity and their relevance to neurodegenerative disease research