APPLICATIONS | EXPERIMENTS

Tissue Sectioning Solutions for Genetic Sequencing

Create healthy, viable tissue slices for genetic sequencing with Precisionary Instruments’ vibratomes.

Get High-Quality, Viable Tissue Slices for Genetic Sequencing

Genetic sequencing studies, such as transcriptomics and single-cell DNA or RNA extraction, require live tissue slices that maintain cellular health and viability to ensure accurate physiological results. Consistently thin, undamaged slices are critical for preserving gene expression and cellular function during sequencing. Precisionary Instruments’ vibratomes are designed to produce precise, viable tissue sections that preserve the physiological integrity of samples, ensuring the most reliable genetic data for downstream analysis.

Compresstome® VF-510-0Z

Precision Vibrating Microtome for Genetic Sequencing

The Compresstome® VF-510-0Z is engineered to produce thin tissue slices while preserving the viability and health of the samples, making it ideal for genetic sequencing applications. This fully automated system ensures tissue sections maintain their physiological integrity, critical for accurate results in studies such as transcriptomics and single-cell DNA or RNA extraction. Experimental applications include:

With a 5-year warranty, the VF-510-0Z offers unmatched reliability and precision for the most demanding genetic sequencing and molecular biology applications.

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References

Hodge RD, Bakken TE, Miller JA, Smith KA, Barkan ER, Graybuck LT, Close JL, Long B, Johansen N, Penn O, Yao Z, Eggermont J, Höllt T, Levi BP, Shehata SI, Aevermann B, Beller A, Bertagnolli D, Brouner K, Casper T, Cobbs C, Dalley R, Dee N, Ding SL, Ellenbogen RG, Fong O, Garren E, Goldy J, Gwinn RP, Hirschstein D, Keene CD, Keshk M, Ko AL, Lathia K, Mahfouz A, Maltzer Z, McGraw M, Nguyen TN, Nyhus J, Ojemann JG, Oldre A, Parry S, Reynolds S, Rimorin C, Shapovalova NV, Somasundaram S, Szafer A, Thomsen ER, Tieu M, Quon G, Scheuermann RH, Yuste R, Sunkin SM, Lelieveldt B, Feng D, Ng L, Bernard A, Hawrylycz M, Phillips JW, Tasic B, Zeng H, Jones AR, Koch C, Lein ES.Conserved cell types with divergent features in human versus mouse cortex. Nature. 2019 Sep;573(7772):61-68. Epub 2019 Aug 21. PMID: 31435019; PMCID: PMC6919571.

Kim EJ, Zhang Z, Huang L, Ito-Cole T, Jacobs MW, Juavinett AL, Senturk G, Hu M, Ku M, Ecker JR, Callaway EM. Extraction of Distinct Neuronal Cell Types from within a Genetically Continuous Population. Neuron. 2020 Jul 22;107(2):274-282.e6. Epub 2020 May 11. PMID: 32396852; PMCID: PMC7381365.

Tasic B, Yao Z, Graybuck LT, Smith KA, Nguyen TN, Bertagnolli D, Goldy J, Garren E, Economo MN, Viswanathan S, Penn O, Bakken T, Menon V, Miller J, Fong O, Hirokawa KE, Lathia K, Rimorin C, Tieu M, Larsen R, Casper T, Barkan E, Kroll M, Parry S, Shapovalova NV, Hirschstein D, Pendergraft J, Sullivan HA, Kim TK, Szafer A, Dee N, Groblewski P, Wickersham I, Cetin A, Harris JA, Levi BP, Sunkin SM, Madisen L, Daigle TL, Looger L, Bernard A, Phillips J, Lein E, Hawrylycz M, Svoboda K, Jones AR, Koch C, Zeng H. Shared and distinct transcriptomic cell types across neocortical areas. Nature. 2018 Nov;563(7729):72-78. Epub 2018 Oct 31. PMID: 30382198; PMCID: PMC6456269.

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Tissue Sectioning Solutions for Genetic Sequencing

Get High-Quality, Viable Tissue Slices for Genetic Sequencing

Precision Vibrating Microtome for Genetic Sequencing

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