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APPLICATIONS | organs

Tissue Sectioning Solutions for Cartilage/Meniscus Research

Create healthy, precise tissue slices from cartilage for studying diseases and cartilage repair using Precisionary Instruments’ vibratome, rotary microtome, and cryostat.

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High-Quality Cartilage Tissue Slices for Osteoarthritis and Regenerative Research

Cartilage is a flexible connective tissue found in joints, nose, ears, and ribs, providing structural support and shock absorption. Research on cartilage is crucial for understanding diseases like osteoarthritis and rheumatoid arthritis, and for developing therapies aimed at cartilage repair and regeneration. Healthy, precise tissue slices are essential for examining the structure, composition, and function of cartilage cells and matrix.

Precisionary Instruments’ Compresstome VF-510-0Z vibratome allows researchers to obtain live cartilage slices for advanced studies, while the RF-1000 rotary microtome and CF-6100 cryostat offer thin, consistent sections for histological analysis. These tools ensure precision and quality in cartilage research.

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Compresstome® VF-510-0Z

Precision Vibrating Microtome for Live Cartilage Tissue Slices

The Compresstome® VF-510-0Z is designed to produce healthy, viable cartilage tissue slices, ideal for studying cartilage structure and function in diseases and regenerative research.

Experimental applications include:

  • Cartilage slices for studying osteoarthritis and cartilage damage
  • Tissue slices for cartilage repair and regeneration research
  • Consistent cartilage sections for drug testing

With a 5-year warranty, the VF-510-0Z ensures precise and reliable sectioning for cartilage research.

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RF 1000 Front Right Angle
RF 1000 Specimen Clamp
RF 1000 Knife Holder Set Knob
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Rotary Microtome RF-1000

Fully Automated Microtome for Thin Cartilage Tissue Sections

The RF-1000 provides thin, uniform cartilage sections for detailed histological studies.

Experimental applications include:

  • Thin cartilage sections for H&E staining
  • Consistent slices for studying cartilage cell composition and structure
  • Reliable sectioning for cartilage histology

With a 3-year warranty, the RF-1000 delivers precise, reproducible sectioning for cartilage research.

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Cryostat CF-6100

Cryostat for Frozen Sectioning of Cartilage Tissue

The CF-6100 cryostat provides frozen sectioning of cartilage tissue, ensuring preservation of structural integrity for detailed histological analysis.

Experimental applications include:

  • Frozen cartilage slices for immunohistochemistry and histology
  • Consistent cartilage sections for structural and compositional analysis
  • Reliable frozen sectioning for cartilage disease research

Acting as a laboratory workhorse, the CF-6100 ensures reliable frozen sectioning for cartilage research over time.

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TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Cartilage/Meniscus Research

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for cartilage/meniscus research, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

  • Intuitive controls
  • Fully programmable ON/OFF control allows automatic system start and stop.
  • Large drain holes that allow easy drainage into trays under all working areas
  • Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
  • Simple maintenance and repair in case of a malfunction

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Real Labs Trust Precisionary Vibratomes for Their Cartilage Tissue Slices

Characterizing Biomechanical and Biotransport Properties of the Meniscus

Dr. Francesco Travascio, Associate Professor at the University of Miami, explores the biomechanical and biotransport properties of the meniscus in relation to its unique structure and composition. In this webinar, Dr. Travascio presents his research on the meniscus’ role in joint function and how understanding its properties can aid in developing regenerative treatments for meniscal injuries.

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References

De Rosa M, Filippone G, Best TM, Jackson AR, Travascio F. Mechanical properties of meniscal circumferential fibers using an inverse finite element analysis approach. J Mech Behav Biomed Mater. 2022 Feb;126:105073. Epub 2022 Jan 5. PMID: 34999488; PMCID: PMC9162054.

Morejon A, Mantero AMA, Best TM, Jackson AR, Travascio F. Mechanisms of energy dissipation and relationship with tissue composition in human meniscus. Osteoarthritis Cartilage. 2022 Apr;30(4):605-612. Epub 2022 Jan 13. PMID: 35032627; PMCID: PMC8940718.

Norberg C, Filippone G, Andreopoulos F, Best TM, Baraga M, Jackson AR, Travascio F. Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition. J Biomech. 2021 May 7;120:110343. Epub 2021 Mar 1. PMID: 33730559; PMCID: PMC8089054.

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