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APPLICATIONS | ANIMALS

Tissue Sectioning Solutions for Non-human Primate Tissue Slicing

Create healthy, viable non-human primate tissue slices for neuroscience, biomedical, and disease research using Precisionary Instruments’ advanced sectioning tools.

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Get High-Quality Non-human Primate Tissue Slices

Non-human primates, such as macaques and baboons, are essential models in biomedical research due to their genetic and physiological similarities to humans. They are particularly useful for studying human diseases such as HIV, Alzheimer’s, Parkinson’s, and cancer, as well as primate-specific diseases like Simian Immunodeficiency Virus (SIV) and Ebola. These animals provide valuable insights into disease mechanisms, progression, and potential treatments.

Non-human primate brain tissue is especially critical for understanding neurodegenerative diseases, cognitive function, and behavior. Other organs, including the heart, liver, and lungs, are studied to model human disease, test therapies, and evaluate medical devices. Precision sectioning of non-human primate tissues maintains cellular integrity and provides reliable results in complex research areas.

Compresstome VF-800-0Z Top Front Right
Compresstome VF-800-0Z Top Front Left
Compresstome VF-800-0Z Front
Compresstome VF-800-0Z Front Blade
Compresstome VF-800-0Z Controls
Compresstome VF-800-0Z Right Side
Compresstome VF-800-0Z Left Side

Compresstome® VF-800-0Z

Precision Vibrating Microtome for Large Non-Human Primate Tissue Samples

The Compresstome® VF-510-0Z is specifically designed to produce healthy, viable acute brain slices for electrophysiology applications. Its fully automated system enables rapid, precise sectioning that increases neuron viability, making it ideal for patch clamping and other electrophysiological studies.

Experimental applications include:

  • Precision-cut brain slices for Alzheimer’s and Parkinson’s research
  • Large organ sections for cardiovascular and liver research
  • Fresh and fixed tissue slices for studying SIV, Ebola, and other diseases

With a 5-year warranty, the VF-800-0Z delivers reliable performance for large non-human primate tissue sectioning.

VIEW SPECS

VF-510-0Z_2a
VF-510-0Z_3a
VF-510-0Z_8a
VF-510-0Z_7a
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VF-510-0Z_1a

Compresstome® VF-510-0Z

Precision Vibrating Microtome for Non-Human Primate Tissue Slices

The VF-510-0Z is ideal for smaller tissue samples, particularly for brain and organ research. It provides consistent slices for neurodegenerative disease research, cognitive function studies, and organ-specific studies. It supports both fresh and fixed tissues, ensuring reliable results.

Experimental applications include:

  • Precision-cut brain slices for neurological and behavioral studies
  • Viable tissue sections for HIV, Alzheimer’s, and cancer research
  • Consistent tissue slices for drug testing and therapeutic development

Supported by a 5-year warranty, the VF-510-0Z ensures accurate and reliable sectioning for primate tissue studies.

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RF 1000 Front Right Angle
RF 1000 Front Left Angle
RF 1000 Front
RF 1000 Foot Press
RF 1000 Cutting Stage Front

Rotary Microtome RF-1000

Fully Automated Microtome for Thin Non-Human Primate Tissue Sections

The RF-1000 provides precision for cutting thin sections of non-human primate tissues, especially brain, liver, and heart tissues. This model is essential for immunohistochemistry and high-resolution imaging, enabling detailed analysis of tissue structures in primate models.

Experimental applications include:

  • Thin brain sections for immunohistochemistry
  • Consistent slices for microscopic imaging of organ structures
  • Reliable sectioning of paraffin-embedded primate tissues for histopathological analysis

With a 3-year warranty, the RF-1000 delivers consistent performance for thin sectioning of primate tissues in research studies.

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6100-freeze-right
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Cryostat CF-6100

Cryostat for Frozen Sectioning of Non-Human Primate Tissues

The CF-6100 cryostat is designed for frozen sectioning of non-human primate tissues, particularly brain and organ samples. It ensures that OCT-embedded tissues maintain their structural integrity, making it ideal for producing frozen sections for immunohistochemistry and advanced imaging.

Experimental Applications Include:

  • Frozen brain sections for Alzheimer’s and neurodegenerative disease research
  • Consistent frozen organ slices for immunohistochemistry and imaging
  • Reliable frozen sectioning for non-human primate tissues in disease research

Acting as a laboratory workhorse, the CF-6100 provides dependable frozen sectioning for long-term studies in non-human primates.

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Paraffin Dispenser Cold plate
Paraffin Dispenser spout
Paraffin Dispenser foot pedal
Paraffin Dispenser front left

TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Non-human Primate Sections

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for non-human primate tissue slicing, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

  • Intuitive controls
  • Fully programmable ON/OFF control allows automatic system start and stop.
  • Large drain holes that allow easy drainage into trays under all working areas
  • Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
  • Simple maintenance and repair in case of a malfunction

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Non-human Primate Tissue Slicing References

Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nat Commun. 2023 Jun 8;14(1):3345. PMID: 37291094; PMCID: PMC10250345.

Kalmbach BE, Hodge RD, Jorstad NL, Owen S, de Frates R, Yanny AM, Dalley R, Mallory M, Graybuck LT, Radaelli C, Keene CD, Gwinn RP, Silbergeld DL, Cobbs C, Ojemann JG, Ko AL, Patel AP, Ellenbogen RG, Bakken TE, Daigle TL, Dee N, Lee BR, McGraw M, Nicovich PR, Smith K, Sorensen SA, Tasic B, Zeng H, Koch C, Lein ES, Ting JT. Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons. Neuron. 2021 Sep 15;109(18):2914-2927.e5. PMID: 34534454; PMCID: PMC8570452.

Xu F, Shen Y, Ding L, Yang CY, Tan H, Wang H, Zhu Q, Xu R, Wu F, Xiao Y, Xu C, Li Q, Su P, Zhang LI, Dong HW, Desimone R, Xu F, Hu X, Lau PM, Bi GQ. High-throughput mapping of a whole rhesus monkey brain at micrometer resolution. Nat Biotechnol. 2021 Dec;39(12):1521-1528. Epub 2021 Jul 26. PMID: 34312500.

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