Upcoming Webinar | Dec. 17 | Serial Compresstome Vibratome Sectioning for Brain Mapping

REGISTER NOW
Request a Quote

APPLICATIONS | OrganS

Tissue Sectioning Solutions for Fixed Brain Slices

Obtain consistent tissue slices from fixed brain samples with Precisionary Instruments’ vibratome, rotary microtome, and cryostat.

Get a Quote

High-Precision Sectioning for Fixed Brain Tissue in Neuroanatomy and Histopathology

Accurate sectioning of fixed brain tissue is essential for studying neuroanatomy, disease models, and histopathological research. Fixed tissues require precise slicing to ensure cellular structures remain intact for staining, imaging, and analysis. 

Precisionary Instruments’ vibratome, rotary microtome, and cryostat are designed to produce consistent, thin sections from fixed brain tissues. These tools help researchers maintain the integrity of delicate brain structures, ensuring high-resolution results for both qualitative and quantitative analyses.

VF-510-0Z_2a
VF-510-0Z_3a
VF-510-0Z_8a
VF-510-0Z_7a
VF-510-0Z_6a
VF-510-0Z_5a
VF-510-0Z_4a
VF-510-0Z_1a

Compresstome® VF-510-0Z

Precision Vibrating Microtome for Fixed Brain Tissue

The Compresstome® VF-510-0Z vibratome is ideal for creating smooth, consistent slices of fixed brain tissue for applications in neuroanatomy and histopathology. This fully automated system produces thin, undamaged sections, preserving the integrity of cellular structures for high-quality results.
Experimental applications include:

  • Sectioning fixed brain tissue for staining and imaging
  • High-resolution sections for histopathological analysis
  • Consistent, undamaged slices for neuroanatomical studies

With a 5-year warranty, the VF-510-0Z delivers unmatched precision for fixed tissue sectioning in brain research.

VIEW SPECS

RF 1000 Front Right Angle
RF 1000 Specimen Clamp
RF 1000 Knife Holder Set Knob
RF 1000 Knife Holder Cutting Stage
RF 1000 Front Left Angle
RF 1000 Front
RF 1000 Foot Press
RF 1000 Cutting Stage Front
RF 1000 Cutting Stage Front Left
RF-1000_Knife-Holder-Only-2-scaled-1-300x200-1.jpg
RF-1000_Specimen-Clamp-1-scaled-1-300x200-2.jpg
RF-1000_Hand-Wheel-1-scaled-1-300x200-1.jpg
RF-1000_Waste-Tray-1-scaled-1-300x200-1.jpg

Rotary Microtome RF-1000

Fully Automated Microtome for Fixed Brain Tissue

The RF-1000 rotary microtome is engineered for repetitive, precise sectioning of fixed brain tissues. This reliable system ensures that slices remain uniform and thin, ideal for detailed histological studies and imaging.
Experimental applications include:

  • Sectioning paraffin-embedded fixed brain tissue for histopathology
  • Consistent sections for advanced neuroanatomical research
  • Reliable tissue slicing for staining and microscopic analysis

With a 3-year warranty, the RF-1000 offers superior stability, making it perfect for repetitive sectioning in brain studies.

VIEW SPECS

6100-freeze-right
6100-front-left
6100-right-hand-wheel
6100-freeze-chamber
6100-controls

Precisionary Cryostat CF-6100

Cryostat for Frozen Sectioning of Fixed Brain Tissue

The CF-6100 cryostat offers reliable and precise sectioning of fixed brain tissue embedded in OCT and frozen for histological studies. Its automated features ensure that tissue integrity is maintained during frozen sectioning, critical for neuroanatomical research.
Experimental applications include:

  • Frozen sectioning of fixed brain tissue for immunohistochemistry
  • Consistent thin slices for detailed neuroanatomy and histopathology
  • Reliable performance for cryosectioning fixed brain tissue samples

Acting as a laboratory workhorse, the CF-6100 ensures reliable frozen sectioning for immunohistochemistry applications over time.

VIEW SPECS

tec-main
Paraffin Dispenser Cold plate
Paraffin Dispenser spout
Paraffin Dispenser foot pedal
Paraffin Dispenser front left

TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Fixed Brain Slices

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for fixed brain slices, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

  • Intuitive controls
  • Fully programmable ON/OFF control allows automatic system start and stop.
  • Large drain holes that allow easy drainage into trays under all working areas
  • Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
  • Simple maintenance and repair in case of a malfunction

VIEW SPECS

Real Labs Trust Precisionary Vibratomes for Their Fixed Brain Slices

“3D” use of animal tissues in experimental design

Have you wondered how one mouse brain may be used for multiple experiments? Come discover the strategy behind using animal tissues for multi-use research experiments, so that your tissue samples can go further. Dr. Yiying Zhang from Harvard Medical School and Massachusetts General Hospital is our guest webinar speaker. For this Precisionary webinar, Dr. Zhang will discuss a “3D” use of animal tissues in planning experimental designs in academic research.

WATCH NOW

From two-dimensional to three-dimensional histopathology using a Compresstome®

Dr. Wong shares how he built a custom-made Compresstome® for high-speed histological 3D imaging of whole organs like brains.

WATCH NOW

Interactions between Saturated Fat, Cytokines, and Microglia in the Ventral Striatum

Dr. Fordahl will highlight how proinflammatory cytokines alter dopamine terminal function, and how increasing dietary fat intake may enhance microglial activity.

WATCH NOW

The locus coeruleus (LC) mediates behavioral flexibility

Dr. Greta Vargova is going to present their most recent publication, in which they show the link between locus coeruleus activity and behavioral flexibility.

WATCH NOW

Let Us Connect You

References

Booeshaghi AS, Yao Z, van Velthoven C, Smith K, Tasic B, Zeng H, Pachter L. Isoform cell-type specificity in the mouse primary motor cortex. Nature. 2021 Oct;598(7879):195-199. Epub 2021 Oct 6. PMID: 34616073; PMCID: PMC8494650.

Driessens SLW, Galakhova AA, Heyer DB, Pieterse IJ, Wilbers R, Mertens EJ, Waleboer F, Heistek TS, Coenen L, Meijer JR, Idema S, de Witt Hamer PC, Noske DP, de Kock CPJ, Lee BR, Smith K, Ting JT, Lein ES, Mansvelder HD, Goriounova NA. Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types. Nat Commun. 2023 Jul 13;14(1):4188. PMID: 37443107; PMCID: PMC10345092. 

Egawa K, Watanabe M, Shiraishi H, Sato D, Takahashi Y, Nishio S, Fukuda A. Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model. Sci Rep. 2023 Apr 17;13(1):5685. PMID: 37069177; PMCID: PMC10110603.

Download Protocol
Download Full Reference List

Request a

Quote

Bring greater precision and consistency to your fixed brain slices. Fill out the form to request a quote from Precisionary Instruments. We’ll respond within one business day. 

Linkedin-in Youtube X-twitter
Company
Contact Us
Applications
Support
Products

Copyright©2024. Precisionary. All rights reserved.

Privacy Policy | Website by Altitude Marketing