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APPLICATIONS | Organs

Tissue Sectioning Solutions for Liver Studies

Create healthy, viable liver tissue slices for PCLS and thin, consistent sections for immunological studies using Precisionary Instruments’ vibratome, rotary microtome, and cryostat.

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High-Quality Liver Tissue Slices for PCLS and Immunological Analysis

Liver tissue sectioning plays a vital role in both precision-cut liver slices (PCLS) for studying organ function and disease models, as well as in preparing thin sections for immunological analysis.

Precisionary Instruments’ Compresstome VF-510-0Z vibratome enables researchers to create healthy, viable PCLS from mouse and human liver tissues, preserving cellular integrity for accurate physiological studies.

For further processing, the RF-1000 rotary microtome and CF-6100 cryostat offer precise, thin sections ideal for immunohistochemistry, staining, and imaging. These tools provide consistent and reliable results, helping advance liver research in both preclinical and clinical applications.

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Compresstome® VF-510-0Z

Precision Vibrating Microtome for Precision-Cut Liver Slices (PCLS)

The Compresstome® VF-510-0Z vibratome is specifically designed to produce healthy, viable liver tissue slices from mouse or human liver. It is ideal for creating precision-cut liver slices (PCLS) for studies in toxicology, liver disease, and organ function. This fully automated system ensures thin, consistent slices while preserving the physiological integrity of liver tissues for accurate research results.

Experimental applications include:

  • Precision-cut liver slices (PCLS) from mouse or human liver for drug screening and liver function studies
  • Viable liver tissue slices for studying disease models and toxicology
  • Consistent sections for studying liver metabolism and therapeutic development

With a 5-year warranty, the VF-510-0Z guarantees precision and reliability for liver tissue sectioning in both preclinical and clinical research.

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Cryostat CF-6100

Cryostat for Frozen Sectioning of Liver Tissue

The CF-6100 cryostat is designed for frozen sectioning of liver tissue, ensuring that liver samples embedded in OCT remain intact during sectioning. This system is ideal for preparing liver sections for immunohistochemical analysis and other advanced research techniques.

Experimental applications include:

  • Frozen sectioning of liver tissue for immunohistochemistry
  • Consistent liver slices for staining and imaging in liver research
  • Reliable performance for frozen liver tissue sectioning for further immunological analysis

Acting as a laboratory workhorse, the CF-6100 ensures reliable frozen sectioning for liver tissue studies over time.

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Rotary Microtome RF-1000

Fully Automated Microtome for Thin Liver Tissue Sections

The RF-1000 rotary microtome is designed to cut very thin, uniform sections of liver tissue, making it ideal for immunological analysis, histopathology, and detailed imaging. Its automated functionality provides consistent results, enabling researchers to study liver morphology and cell structure.

Experimental applications include:

  • Thin liver tissue sections for immunohistochemistry and staining
  • Consistent liver slices for microscopic imaging and analysis
  • Reliable sectioning of paraffin-embedded liver tissues for immunological research

With a 3-year warranty, the RF-1000 delivers superior performance in repetitive, thin sectioning for liver studies.

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TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Liver Studies

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for liver studies, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

  • Intuitive controls
  • Fully programmable ON/OFF control allows automatic system start and stop.
  • Large drain holes that allow easy drainage into trays under all working areas
  • Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
  • Simple maintenance and repair in case of a malfunction

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Real Labs Trust Precisionary Vibratomes for Liver Tissue Slicing

Making Precision-Cut Tissue Slices for Ex Vivo Assay Services

Visikol is a contract research services company focused on leveraging advanced imaging, 3D cell culture assays and digital pathology to accelerate the drug discovery and development process. In this webinar, Visikol explains the need for in vitro liver models to study livery injury. They demonstrate the standard assay format for creating precision-cut liver slices (PCLS), and explain how the Compresstome® VF-310-0Z vibrating microtome helps create uniform tissue slices that can be meaningfully compared between treatments. Visikol goes through how to use the Compresstome® step-by-step for making PCLS.

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Investigating Liver Metabolism and Inflammation with Precision-Cut and Histological Liver Sections

Dr. Sui-Seng Tee, a researcher at the University of Maryland, uses the Compresstome® vibratome to create both precision-cut liver slices (PCLS) for live tissue studies and fixed liver sections for histological analysis. In this webinar, Dr. Tee explores how these techniques enable the investigation of nutrient metabolism and liver inflammation, shedding light on metabolic changes in liver diseases and minimally invasive detection methods.

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References

Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022 Feb 8;55(2):254-271.e7. PMID: 35139352; PMCID: PMC8852844.

Liu P, Anandhan A, Chen J, Shakya A, Dodson M, Ooi A, Chapman E, White E, Garcia JG, Zhang DD. Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biol. 2023 Feb;59:102570. Epub 2022 Dec 5. PMID: 36495698; PMCID: PMC9731892.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 Mar;603(7902):736-742. Epub 2022 Mar 9. PMID: 35264794; PMCID: PMC9014868.

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