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Tissue Sectioning Solutions for Lymph Node Slicing

Create healthy, viable lymph node tissue slices for immunology and disease research using Precisionary Instruments’ advanced sectioning tools.

Get High-Quality Lymph Node Tissue Slices

Lymph nodes are small, bean-shaped structures that play a crucial role in the immune system by filtering lymphatic fluid and trapping harmful particles, such as bacteria and viruses. They house immune cells, such as lymphocytes and macrophages, which help identify and destroy pathogens.

Tissue sectioning is essential to study the immune functions of lymph nodes, providing thin, flat samples for microscopic observation. These tissue sections allow researchers to explore processes like antigen presentation, T cell activation, and antibody production. Lymph node tissue research is vital in understanding lymphatic disorders, such as lymphoma and lymphedema, and plays a key role in cancer immunotherapy and infectious disease research.

Compresstome® VF-510-0Z

Precision Vibrating Microtome for Lymph Node Tissue Slices

The VF-510-0Z vibratome is specifically designed to produce precise, healthy slices of lymph nodes for immunological studies. It ensures consistent tissue sectioning, preserving the structural integrity of cells and immune components. This model supports both fresh and fixed tissue sectioning, making it ideal for cancer research and autoimmune studies.

Applications Include:

With a 5-year warranty, the VF-510-0Z ensures reliable, high-quality tissue sectioning for immunology research.

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Rotary microtome rf-1000

Fully Automated Microtome for Thin Lymph Node Tissue Sections

The RF-1000 rotary microtome provides exceptional precision for cutting thin lymph node sections. It is essential for immunohistochemistry, high-resolution imaging, and histopathological analysis, allowing for detailed examination of immune cell structure and lymphatic function.

Applications Include:

With a 3-year warranty, the RF-1000 delivers precise and consistent sectioning for lymph node tissue research.

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Cryostat CF-6100

Cryostat for Frozen Sectioning of Lymph Node Tissue

The CF-6100 cryostat is designed to produce high-quality frozen sections of lymph nodes, preserving the integrity of OCT-embedded samples. It is essential for immunohistochemical analysis and imaging studies focused on lymphatic function, immune responses, and disease processes.

Applications Include:

Acting as a laboratory workhorse, the CF-6100 ensures dependable frozen sectioning for immunology and lymphatic disease research.

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TEC-200 Tissue Embedding Center

Efficient Tissue Processing for Lymph Node Slicing

The TEC-200 Tissue Embedding Center is designed for seamless embedding. It offers automation for precise and consistent results. Ideal for lymph node slicing, its ergonomic design ensures operator comfort. Experience stability and precision cutting, and elevate your tissue processing with the TEC-200 from Precisionary Instruments.

Intuitive controls
Fully programmable ON/OFF control allows automatic system start and stop.
Large drain holes that allow easy drainage into trays under all working areas
Trimming plates on both sides, as well as a separate heated and cooling workstation, allow easy workflow
Simple maintenance and repair in case of a malfunction

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Real Labs Trust Precisionary Vibratomes for Lymph Node Tissue Slicing

Investigating Vaccine Adjuvant-Induced Inflammation with Precision-Cut Lymph Node Slices

Dr. Joannah Fergusson, Scientific Officer at the University of Oxford, utilizes the Compresstome® vibratome to create precision-cut slices of human lymph nodes for studying inflammation caused by vaccine adjuvants. In this webinar, Dr. Fergusson discusses how these tissue slices are vital for understanding early immune responses, helping to design more effective vaccines and explore common inflammatory pathways for potential therapies.

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Exploring HIV Antigen Persistence in Lymph Nodes Using Precision-Cut Sections

Dr. Omolara Baiyegunhi, a Wellcome Trust fellow at the Africa Health Research Institute, utilizes the Compresstome® vibratome to create precision-cut lymph node sections for studying HIV persistence during antiretroviral therapy (ART). In this webinar, Dr. Baiyegunhi discusses how these sections provide critical insights into the immune responses in lymph nodes, informing strategies to eradicate HIV reservoirs and improve therapeutic approaches.

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Using the Compresstome® in Immunotherapy Research

Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.

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In Situ MHC-tetramer Staining & Quantitative Analysis of Antigen-specific CD8 T Cells in Tissues

The Compresstome® isn’t just able to cut thinner than the competition, we believe that the evidence shows that we also provide higher quality cuts that preserve cell surface structures and help increase the number of healthy to dead cells. Researchers at University of Minnesota use a Compresstome® to section live tissue in their procedure to locate, quantify, and phenotype antigen-specific CD8 T cells.

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Slicing up the tumor: Lessons from attempted lung tumor slice cultures

Dr. Tsilingiri is working on tumor immunotherapy and using the Compresstome vibrating microtome to examine the interaction between tumor tissues and autologous lymph node cells in slice cultures. This work is being carried out in the frame of an EU-funded Consortium, Tumour-LNoC (Tumour-Lymph node on a chip), with the ultimate goal of mimicking the metastatic process on a chip and monitor metastasizing cells in real time.

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References

Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. Nat Methods. 2020 Aug;17(8):833-843. Epub 2020 Jul 6. PMID: 32632238; PMCID: PMC7891292.

Li S, Folkvord JM, Kovacs KJ, Wagstaff RK, Mwakalundwa G, Rendahl AK, Rakasz EG, Connick E, Skinner PJ. Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection. PLoS Pathog. 2019 Mar 21;15(3):e1007311. PMID: 30897187; PMCID: PMC6445460.

Webb GM, Li S, Mwakalundwa G, Folkvord JM, Greene JM, Reed JS, Stanton JJ, Legasse AW, Hobbs T, Martin LD, Park BS, Whitney JB, Jeng EK, Wong HC, Nixon DF, Jones RB, Connick E, Skinner PJ, Sacha JB. The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles. Blood Adv. 2018 Jan 23;2(2):76-84. PMID: 29365313; PMCID: PMC5787870.

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Bring greater precision and consistency to your lymph node tissue slices. Fill out the form to request a quote from Precisionary Instruments. We’ll respond within one business day.

Tissue Sectioning Solutions for Lymph Node Slicing

Get High-Quality Lymph Node Tissue Slices

Precision Vibrating Microtome for Lymph Node Tissue Slices

Fully Automated Microtome for Thin Lymph Node Tissue Sections

Cryostat for Frozen Sectioning of Lymph Node Tissue

Efficient Tissue Processing for Lymph Node Slicing

Real Labs Trust Precisionary Vibratomes for Lymph Node Tissue Slicing

Investigating Vaccine Adjuvant-Induced Inflammation with Precision-Cut Lymph Node Slices

Exploring HIV Antigen Persistence in Lymph Nodes Using Precision-Cut Sections

Using the Compresstome® in Immunotherapy Research

In Situ MHC-tetramer Staining & Quantitative Analysis of Antigen-specific CD8 T Cells in Tissues

Slicing up the tumor: Lessons from attempted lung tumor slice cultures

References

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