Compresstome Neuron Viability
Compresstome® produces brain slices with higher neuronal viability: This study demonstrates significantly higher proportions of live neurons in many brain regions from slices cut with a Compresstome® vibrating microtome, compared to other vibratomes.

Problems with other market slicers

Advantages of the Compresstome®


Microtomes from Precisionary Instruments have been used by labs around the world, and cited in hundreds of peer-reviewed publications. Explore these references by experiment, animal model, and organ system. For convenience, we also put together key experimental protocols to help you.


Neuroscience at the Allen Institute

Often heralded as leaders in the field, the Allen Brain institute performs pioneering research on all manner of brain tissue. Working with brain tissue can often be as frustrating as it is rewarding. For over a decade, researchers at the Allen Institute for Brain Science have been using the Compresstome® vibrating microtome to help give them better brain slices with increased longevity and reduced damage to surface neurons. This enables neuroscientists to have healthy neurons for patch-clamp electrophysiology experiments. This video takes you on a virtual tour of whole cell patch clamp electrophysiology at the Allen Institute for Brain Science.

Reflections on a decade of patching in adult brain slices

Jonathan T. Ting is an Assistant Investigator at the Allen Institute, where he joined in 2013 to provide electrophysiology expertise for the Human Cell Types program, and to develop functional assays on human ex vivo brain slides. Dr. Ting has more than 15 years of experience in patch clamp electrophysiology. In this webinar, Dr. Ting provides reflections of his experience on a decade of patching adult brain slices. He discusses which key steps in the brain slice process is most important and why, and challenges our conventional beliefs of slicing solutions and methodologies. Finally, he provides recommended tips and tricks based on his experience and research

Using electrophysiological methods to examine e-cigarette flavors’ effect on dopamine neuron function

Dr. Henderson is an Assistant Professor in the Department of Biomedical Sciences at Marshall University’s Joan C. Edwards School of Medicine. In addition, Dr. Henderson is now one of two co-Chairs for the Basic Science Network in the Society for Research on Nicotine and Tobacco (www.SRNT.org). The Henderson lab focuses on the role tobacco and vaping flavors play in addiction-related behaviors, and uses the Compresstome® vibrating microtome to make all of their acute brain slices for patch-clamp electrophysiology. Thus far, they have shown that menthol and green apple flavors can enhance nicotine vapor self-administration and do so by directly altering dopamine neurons in the midbrain.

Compresstome® for sectioning live myocardial slices for cardiac research

The Smyth Laboratory, led by James Smyth, Ph.D., studies cardiomyopathy at a subcellular level, searching for  potential targets for therapeutic interventions to help restore normal cardiac function to diseased hearts. In this video, Dr. James Smyth shows how to section live myocardial slices with the Precisionary Instrument’s Compresstome®, and uses them for tissue culture and calcium imaging.

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