Histology & Pathology
Histopathology is the study of disease by using a microscope to examine tissues or surgical biopsies that are processed, fixed, sectioned, and plated onto glass slides. Tissue slices are then processed by staining, where different dyes and antibodies help visualize specific components of tissues and proteins. Hematoxylin-Eosin (H&E) staining has been used in pathology for over a century.
Because histopathology requires extremely fine and thin tissue sections (often down to 5µm or thinner), obtaining consistent sections is crucial for further processing. The process of cutting tissue slices also needs to occur rapidly because serial sections are needed. Therefore, histology and pathology require a rotary microtome that can quickly make high quality thin tissue slices without friction, chattermarks, or inconsistencies.