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Why Precisionary Microtomes?

  • Durability: Durable build with an industry leading 3 year warranty
  • Full Product line: available in automatic, semi-automatic, and manual (links for all) models
  • Easy to own: Solid supply chain and repair channels to ensure availability for your purchase and your maintenance.
  • Turnkey solution: All you need to get started comes with your microtome, so you can hit the ground running.
  • Affordable: The entire setup will not cost you an arm and a leg, leaving you budget to invest in other equipment.

 

Histopathology is the study of disease by using a microscope to examine tissues or surgical biopsies that are processed, fixed, sectioned, and plated onto glass slides. Tissue slices are then processed by staining, where different dyes and antibodies help visualize specific components of tissues and proteins. Hematoxylin-Eosin (H&E) staining has been used in pathology for over a century.

Because histopathology requires extremely fine and thin tissue sections (often down to 5µm or thinner), obtaining consistent sections is crucial for further processing. The process of cutting tissue slices also needs to occur rapidly because serial sections are needed. Therefore, histology and pathology require a rotary microtome that can quickly make high quality thin tissue slices without friction, chattermarks, or inconsistencies.

Recommended Models

VF-510-0Z

Compresstome vibrating microtome

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RF-1000

Rotary microtome

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Not sure which model is right for your needs?

Real lab examples

See our Rotary Microtome RF-1000 in action!

Our rotary microtome RF-1000 is a fully automated microtome. Check out its keys features, and see it cutting specimen samples in this short video.

Using the Compresstome® in Immunotherapy Research

Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.

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Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology

Explore how scientists use the Compresstome® vibrating microtome to create tissue slices that combine lipophilic dye tracing, whole mount in situ hybridizationimmunohistochemistry, and histology to extract the maximal possible amount of data.

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Slicing up the tumor: Lessons from attempted lung tumor slice cultures

Dr. Tsilingiri is working on tumor immunotherapy and using the Compresstome vibrating microtome to examine the interaction between tumor tissues and autologous lymph node cells in slice cultures. This work is being carried out in the frame of an EU-funded Consortium, Tumour-LNoC (Tumour-Lymph node on a chip), with the ultimate goal of mimicking the metastatic process on a chip and monitor metastasizing cells in real time.

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From two-dimensional to three-dimensional histopathology using a Compresstome®

Dr. Wong shares how he built a custom-made Compresstome® for high-speed histological 3D imaging of whole organs like brains.

References

Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nat Commun. 2023 Jun 8;14(1):3345. PMID: 37291094; PMCID: PMC10250345. Download PDF

Mastorakos P, Mihelson N, Luby M, Burks SR, Johnson K, Hsia AW, Witko J, Frank JA, Latour L, McGavern DB. Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury. Nat Neurosci. 2021 Feb;24(2):245-258. Epub 2021 Jan 18. PMID: 33462481; PMCID: PMC7854523. Download PDF

Rindner DJ, Proddutur A, Lur G. Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex. Neuron. 2022 Nov 16;110(22):3760-3773.e5. Epub 2022 Sep 9. PMID: 36087582; PMCID: PMC9671855. Download PDF

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