Dr. Junshi Wang is a translational neuroscientist investigating the cellular and circuit mechanisms of neurological and psychiatric disorders. His work integrates transcriptomic, neurophysiological, and behavioral approaches to define mechanisms of action and to identify and validate circuit-based therapeutic targets. In this webinar, Dr. Wang will share how he built this multimodal strategy, from target hypothesis to circuit-level validation, along with case examples of how it uncovered the cellular and circuit substrates driving CNS diseases.
In this webinar, Dr. Wang will:
- Describe how astrocyte-mediated synaptogenesis is characterized using electrophysiology and imaging to nominate glial-neuronal targets for psychiatric and pain indications
- Explain how single-cell transcriptomics and connectomics are applied to prioritize candidate circuits and cell-type targets across CNS disease models
- Walk through case examples that trace a target from initial hypothesis to circuit-level validation