Dr. Régis Joulia is an Advanced Research Fellow and Wellcome Trust-funded Group Leader at the National Heart & Lung Institute (NHLI), where he established his independent research group in January 2024. His laboratory investigates how immune cell activation influences pulmonary vascular remodeling during respiratory disease, with a particular focus on understanding how inflammation alters blood vessel organization and tissue architecture within the lung.
By combining advanced imaging approaches with precision-cut lung slices (PCLS), Dr. Joulia’s research seeks to better understand the spatial organization of immune cells within intact lung tissue and how these dynamic interactions contribute to allergic and inflammatory lung diseases. This three-dimensional tissue platform preserves native tissue architecture, enabling researchers to study immune responses in a physiologically relevant environment that cannot be achieved with conventional tissue sections.
In this webinar, Dr. Joulia will:
•Explain how precision-cut lung slices can be used to investigate three-dimensional immune cell distribution within intact lung tissue.
•Discuss the advantages of lung PCLS over formalin-fixed paraffin-embedded (FFPE) and fresh-frozen tissue sections for studying immune responses.
•Demonstrate how PCLS are used to investigate immune cell organization during allergen-induced lung inflammation.
Explore future applications of PCLS for studying lung biology, mucosal immunity, and respiratory disease.