The studies of Dr. Andreacarola Urso have largely focused on different phases of lung disease, including respiratory disease progression, transplantation and graft rejection. Currently, Dr. Urso’s chief area of interest is immunometabolism in the context of bacterial pneumonias in cystic fibrosis, which also eventually leads to lung transplantation. Pharmacological testing as well as mechanical responses are challenging to study in the human lung. Dr. Urso will talk about how the use of precision-cut lung slices (PCLS) has facilitated her studies on airway contractility and pharmacological delivery.

In this webinar, Dr. Urso will:

  • Discuss the use of human and mouse lung tissue for PCLS
  • Explain how lung PCLS can be used to measure airway contractility and gene expression in airway smooth muscle
  • Explain how lung PCLS can be used for TEM analysis of drug delivery efficiency