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Tissue Sectioning Solutions for Heart/Cardiac Studies

Create healthy, viable cardiac tissue slices for electrophysiology and thin, consistent sections for heart histology using Precisionary Instruments’ vibratome, rotary microtome, and cryostat.

High-Quality Cardiac Tissue Slices for Electrophysiology and Histological Analysis

Cardiac tissue sectioning is essential for both live tissue studies in electrophysiology and detailed histological analysis of heart pathology and anatomy.

Precisionary Instruments’ Compresstome VF-510-0Z vibratome produces healthy, viable cardiac tissue slices for electrophysiology experiments, allowing researchers to record from pacemaker cells, myocytes, and other cardiac cells.

For further histological processing, the RF-1000 rotary microtome and CF-6100 cryostat offer thin, consistent tissue sections ideal for H&E staining and other histology studies of cardiac structure and pathology. These tools provide researchers with reliable and precise tissue slices for a variety of cardiac research applications.

Compresstome® VF-510-0Z

Precision Vibrating Microtome for Live Cardiac Tissue Slices

The Compresstome® VF-510-0Z is designed to produce live, viable cardiac tissue slices for electrophysiology experiments. These thin, healthy slices allow researchers to study heart cells, such as pacemaker cells and myocytes, in a controlled environment, making it ideal for studies on cardiac function, arrhythmias, and electrophysiology.
Experimental applications include:

With a 5-year warranty, the VF-510-0Z delivers precise and reliable sectioning for live cardiac tissue in electrophysiology research.

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Rotary Microtome RF-1000

Fully Automated Microtome for Thin Cardiac Tissue Sections

The RF-1000 rotary microtome is ideal for cutting thin, uniform cardiac tissue sections for histological studies. This automated system ensures consistent sectioning, making it suitable for H&E staining and detailed studies of cardiac pathology and anatomy.

Experimental applications include:

With a 3-year warranty, the RF-1000 provides precise, reproducible sectioning for heart tissue in histological studies.

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Cryostat CF-6100

Cryostat for Frozen Sectioning of Cardiac Tissue

The CF-6100 cryostat is designed for frozen sectioning of cardiac tissue, ensuring the preservation of tissue integrity while producing thin sections for histology and imaging studies.

Experimental applications include:

Acting as a laboratory workhorse, the CF-6100 ensures reliable frozen sectioning for heart tissue studies over time.

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Real Labs Trust Precisionary Vibratomes for Heart Tissue Slicing

Compresstome® for sectioning live myocardial slices for cardiac research

The Smyth Laboratory, led by James Smyth, Ph.D., studies cardiomyopathy at a subcellular level, searching for potential targets for therapeutic interventions to help restore normal cardiac function to diseased hearts. Here, Dr. Smyth shows how to section live myocardial slices with the Compresstome®, and uses them for tissue culture and calcium imaging.

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Investigating Ventricular Wall Morphogenesis with the Compresstome® Vibratome

Dr. Mingfu Wu, Associate Professor of Pharmacology at the University of Houston, uses the Compresstome® vibratome to create precise heart tissue sections for studying ventricular wall development. In this webinar, Dr. Wu explores how disruptions in cellular organization contribute to congenital heart defects, offering insights into cardiomyocyte interactions and the role of β1 integrins in heart morphogenesis.

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References

Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P,Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH. In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun. 2021 Jul 13;12(1):4291. PMID: 34257302; PMCID: PMC8277817.

Li Z, Solomonidis EG, Berkeley B, Tang MNH, Stewart KR, Perez-Vicencio D, McCracken IR, Spiroski AM, Gray GA, Barton AK, Sellers SL, Riley PR, Baker AH, Brittan M. Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart. Cardiovasc Res. 2023 Mar 17;119(1):136-154. PMID: 36082978; PMCID: PMC10022865.

Wen Q, Gandhi K, Capel RA, Hao G, O’Shea C, Neagu G, Pearcey S, Pavlovic D, Terrar DA, Wu J, Faggian G, Camelliti P, Lei M. Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca<sup>2+</sup> transients in murine heart. J Physiol. 2018 Sep;596(17):3951-3965. Epub 2018 Jul 26. PMID: 29928770; PMCID: PMC6117587.

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Bring greater precision and consistency to your heart tissue slices. Fill out the form to request a quote from Precisionary Instruments. We’ll respond within one business day.

Tissue Sectioning Solutions for Heart/Cardiac Studies

High-Quality Cardiac Tissue Slices for Electrophysiology and Histological Analysis

Precision Vibrating Microtome for Live Cardiac Tissue Slices

Fully Automated Microtome for Thin Cardiac Tissue Sections

Cryostat for Frozen Sectioning of Cardiac Tissue

Real Labs Trust Precisionary Vibratomes for Heart Tissue Slicing

Compresstome® for sectioning live myocardial slices for cardiac research

Investigating Ventricular Wall Morphogenesis with the Compresstome® Vibratome

References

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