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Tissue Sectioning Solutions for Electrophysiology

Produce healthy, viable brain slices rapidly with Precisionary Instruments’ Compresstome vibratome, designed to enhance neuronal viability for electrophysiology studies such as patch clamping.

Get Healthy Tissues Slices Perfect for Electrophysiology

The Compresstome® family of vibrating microtomes produces thin and consistent tissue slices to reduce variability in experimental data and enhance the reliability and reproducibility of electrophysiological studies.

Making healthy tissue slices with a vibratome is critical for electrophysiological studies. High-quality slices allow researchers to study the electrical activity of neurons in a controlled and precise manner by enabling accurate recordings of neuronal responses and facilitating the analysis of synaptic transmission, ion channels, and membrane properties.

Without high-quality tissue sections, it can be difficult to produce reliable and consistent results in your study.

Compresstome® VF-510-0Z

Rapid, High-Viability Sectioning for Electrophysiology

The Compresstome® VF-510-0Z is specifically designed to produce healthy, viable acute brain slices for electrophysiology applications. Its fully automated system enables rapid, precise sectioning that increases neuron viability, making it ideal for patch clamping and other electrophysiological studies. Experimental applications include:

With a 5-year warranty, the VF-510-0Z ensures precise, rapid sectioning to support the highest quality results in electrophysiology, preserving the health of brain tissue and neurons.

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Compresstome® VF-210-0Z

Semi-automated Vibrating Microtome

Our Compresstome® VF-210-0Z is a vibrating microtome great for sectioning fresh tissues.

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Real Labs Trust Precisionary Vibratome for Their Electrophysiology Experiments

Neuroscience at the Allen Institute

For over a decade, researchers at the Allen Institute for Brain Science — often heralded as leaders in the field — have been using the Compresstome® vibrating microtome to help give them better brain slices with increased longevity and reduced damage to surface neurons.

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Reflections on a Decade of Patching in Adult Brain Slices

Dr. Jonathan T. Ting, Assistant Investigator at the Allen Institute, has been utilizing the Compresstome® vibratome for over a decade to create precise brain slices for electrophysiology studies. In this webinar, Dr. Ting shares key insights into the brain slice preparation process and discusses how the Compresstome® has played a pivotal role in advancing research on human ex vivo brain tissues.

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Synaptic and Circuit Changes in Neurodevelopmental Disorders

Dr. Ben Richardson, Assistant Professor of Pharmacology at Southern Illinois University, explores how environmental and genetic factors disrupt neural circuits in models of Autism Spectrum Disorder and ADHD. In this webinar, Dr. Richardson highlights the use of the Compresstome® vibratome to create precise brain tissue sections, enabling his lab to examine synaptic changes and their impact on behavior.

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Auditory Processing Disruptions in Neurodevelopmental Disorders

Dr. Schmid, Professor and Vice Dean at the Schulich School of Medicine & Dentistry, investigates how sensory processing is altered in rodent models of neurodevelopmental disorders. This webinar showcases the use of the Compresstome® vibratome to create high-quality brain sections for studying auditory disruptions, providing insights into sensory-related cognitive changes.

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References

Driessens SLW, Galakhova AA, Heyer DB, Pieterse IJ, Wilbers R, Mertens EJ, Waleboer F, Heistek TS, Coenen L, Meijer JR, Idema S, de Witt Hamer PC, Noske DP, de Kock CPJ, Lee BR, Smith K, Ting JT, Lein ES, Mansvelder HD, Goriounova NA. Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types. Nat Commun. 2023 Jul 13;14(1):4188. PMID: 37443107; PMCID: PMC10345092.

Godino A, Salery M, Durand-de Cuttoli R, Estill MS, Holt LM, Futamura R, Browne CJ, Mews P, Hamilton PJ, Neve RL, Shen L, Russo SJ, Nestler EJ. Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. Neuron. 2023 May 3;111(9):1453-1467.e7. Epub 2023 Mar 7. PMID: 36889314; PMCID: PMC10164098.

Li L, Durand-de Cuttoli R, Aubry AV, Burnett CJ, Cathomas F, Parise LF, Chan KL, Morel C, Yuan C, Shimo Y, Lin HY, Wang J, Russo SJ. Social trauma engages lateral septum circuitry to occlude social reward. Nature. 2023 Jan;613(7945):696-703. Epub 2022 Nov 30. PMID: 36450985; PMCID: PMC9876792.

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Tissue Sectioning Solutions for Electrophysiology

Get Healthy Tissues Slices Perfect for Electrophysiology

Rapid, High-Viability Sectioning for Electrophysiology

Semi-automated Vibrating Microtome

Real Labs Trust Precisionary Vibratome for Their Electrophysiology Experiments

Neuroscience at the Allen Institute

Reflections on a Decade of Patching in Adult Brain Slices

Synaptic and Circuit Changes in Neurodevelopmental Disorders

Auditory Processing Disruptions in Neurodevelopmental Disorders

References

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