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COMPRESSTOME® VF-510-0Z

Ultra-Precise & Consistent Vibrating Microtome

Our VF-510-0Z Compresstome® tissue slicer is a top of the line vibrating microtome that can be used for all of your live or fixed tissue sectioning needs.

  • Great for live AND fixed tissues.
  • Consistent, high quality slices
  • Highly viable cells.
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Key Features of the VF-510-0Z Vibratome

VF 510 0Z Features

Durable: Equipped with a powerful, cordless motor for quiet and durable operation

Compact design: A fraction of the size of a legacy Vibratome, the Compresstome can easily fit into a hood, and takes much less space on your bench

Fast loading of cutting samples: Our one-touch unlocking mechanism on the sliding control box allows for rapid sample loading

User-friendly controls: Fully integrated control box has intuitive control parameters for controlling tissue sectioning

Compatible with multiple blade types: New magnetic blade holder allows for easy magnetic attachment of stainless steel blades, or glue-on attachment of ceramic and tungsten blades

Easy to clean: Removable buffer tray and tube base allow for easy cleaning and changing tube sizes

Increased lifespan of microtome: Built-in see-through cover protects oscillating parts from aerosolized buffer solution.

What Sets the VF-510-0Z Vibrating Microtome Apart

Cell Viability

The VF-510-0Z’s fast slicing technique preserves cell viability, making it ideal for live tissue experiments like ephys, ensuring cells remain functional and intact.

Consistent Results

With the Auto Zero-Z feature, the VF-510-0Z provides highly consistent and reproducible slices, enhancing experimental reliability.

Product Reliability

Backed by a 5-year warranty, the VF-510-0Z offers long-term reliability, giving users peace of mind that the product is built to last.

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The VF-510-0Z Compresstome® is designed to be the most consistent and reliable vibrating microtome on the market.
Get a 360-degree view of this cutting-edge instrument, and explore key features below:

VF-510-0Z Technical Specifications

Advance speed

0-4 mm/s, adjustable

Return speed

6 mm/s, fixed

Vibration frequency

0-65 Hz, adjustable

Vibration amplitude

1.2 mm, fixed

Z-Axis vibration

~0 um

Compatible cutting blades

Double-edge stainless steel blades, Ceramic blades, Tungsten carbide blades

Cutting angle

20 degrees, fixed

Thickness adjustment

Automatic, digital

Micrometer resolution

1 um

Maximum tissue diameter

15.5 mm, 20 mm

Maximum tissue length

22 mm

Slice thickness range

1 um to 999um Quality tested to cut below 10 um (can cut as low as 4 um depending on tissue type)

Cutting modes

Single or continuous, selectable

Buffer tray size (L x W x H)

110 x 60 x 30 mm

Power source

110-240V AC

Power consumption

18 W

Dimensions (L x W x H)

330 x 255 x 195 mm

Weight

6 kg

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Key Application Areas

Experiments

Electrophysiology

Immunohistochemistry

Histopathology

High-throughput sectioning

Large sample (whole organ) sectioning

Precision-cut tissue slices (PCTS)

Imaging

Electron microscopy

Genetic Sequencing (Single-Cell Isolation)

In-situ hybridization

Material & Bio-engineering (Polymers)

Organoids

Organotypic slice culture

Plant research

Organ Systems

Brain (fixed)

Brain (live or acute)

Cartilage

Embryo

Eye

Gut (intestines)

Heart

Kidney

Liver

Lung

Lymph nodes

Animal Models

Mouse

Rat

Human

Non-human primates

Bird (Zebra finch)

Chick

Fish

Frog

Pig

Compresstome® References

The Compresstome® family of vibrating microtomes has been used in many peer-reviewed studies for successful tissue slices. Here are some of our top references. Please contact us for a full list of references or for references specific to your application.

Let us connect you with one of our references.

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1.

Buffington SA, Di Prisco GV, Auchtung TA, Ajami NJ, Petrosino JF, Costa-Mattioli M.
Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell. 2016 Jun 16;165(7):1762-75. PMID: 27315483; PMCID: PMC5102250.

2.

Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA.
Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature. 2015 Nov 12;527(7577):240-4. PMID: 26560302; PMCID: PMC4765808.

3.

Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ.
Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. PMID: 27071111; PMCID: PMC4855555.

4.

Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW.
The mouse cortico-striatal projectome. Nat Neurosci. 2016 Aug;19(8):1100-14. PMID: 27322419.

5.

Kim S, Ma L, Yu CR. 
Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons. Nat Commun. 2011 Jun 21;2:365. PMID: 21694713; PMCID: PMC3156823.

6.

Kim S, Ma L, Jensen KL, Kim MM, Bond CT, Adelman JP, Yu CR.
Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ. Nat Neurosci. 2012 Sep;15(9):1236-44. PMID: 22842147; PMCID: PMC3431453.

7.

Kuo CS, Krasnow MA.
Formation of a Neurosensory Organ by Epithelial Cell Slithering. Cell. 2015 Oct 8;163(2):394-405. PMID: 26435104; PMCID: PMC4597318.

8.

Mylvaganam GH, Rios D, Abdelaal HM, Iyer S, Tharp G, Mavinger M, Hicks S, Chahroudi A, Ahmed R, Bosinger SE, Williams IR, Skinner PJ, Velu V, Amara RR.
Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1976-1981. PMID: 28159893; PMCID: PMC5338410.

9.

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK.
Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016;1. pii: 0004. PMID: 28966873; PMCID: PMC5621647.

10.

Pan BX, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A.
Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron. 2009 Mar 26;61(6):917-29. PMID: 19324000; PMCID: PMC2673456.

11.

Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G.
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011 Apr 28;472(7344):437-42. PMID: 21423165; PMCID: PMC3090611

12.

Wickersham IR, Sullivan HA, Seung HS.
Axonal and subcellular labelling using modified rabies viral vectors. Nat Commun. 2013;4:2332. PMID: 23945836.

13.

Yang WZ, Liu TT, Cao JW, Chen XF, Liu X, Wang M, Su X, Zhang SQ, Qiu BL, Hu WX, Liu LY, Ma L, Yu YC.
Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. PMID: 27071111; PMCID: PMC4855555.

14.

Yao XH, Wang M, He XN, He F, Zhang SQ, Lu W, Qiu ZL, Yu YC.
Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex. Nat Commun. 2016 Aug 11;7:12229. PMID: 27510304; PMCID: PMC4987578.

15.

Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM.
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci. 2014 Jan 1;34(1):79-94. PMID: 24381270; PMCID: PMC3866496.

16.

Zhao S, Ting JT, Atallah HE, Qiu L, Tan J, Gloss B, Augustine GJ, Deisseroth K, Luo M, Graybiel AM, Feng G.
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods. 2011Sep;8(9):745-52. PMID: 21985008; PMCID: PMC3191888.

17.

Zingg B, Hintiryan H, Gou L, Song MY, Bay M, Bienkowski MS, Foster NN, Yamashita S, Bowman I, Toga AW, Dong HW.
Neural networks of the mouse neocortex. Cell. 2014 Feb 27;156(5):1096-111. PMID: 24581503; PMCID: PMC4169118.
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Researchers Trust Precisionary

Dr. Charlotte Dean

Imperial College London

We have used Compresstome tissue slicers for a number of years to generate lung slices (PCLS). Customer service has always been excellent and the team are very responsive. We have recently begun using the VF-510-0Z machine and it is generating high quality PCLS.

Dr. Hanan Osman-Ponchet

University of Burgundy

The Compresstome® VF-300-0Z has been an indispensable tool in our PKDERM lab for preparing high-quality human precision-cut lung slices (hPCLS).

Its versatility and rapid sectioning capabilities have enabled us to efficiently generate these valuable samples for our lung research studies. We have consistently achieved excellent section thickness and quality, allowing us to conduct detailed analyses of lung physiology and pathology and to obtain reliable results from our experiments.

The exceptional customer service from Precisionary Instruments has further enhanced our experience. Their prompt and knowledgeable support has been instrumental in ensuring the optimal performance of our Compresstome®.

Dr. Susanne Schmid

University of Western Ontario

We use brainstem slices of rats, which are particularly delicate and difficult to obtain. We were surprised by the performance of the vibratome, as it produces healthy brain slices comparable to much more expensive vibratomes. I also like the simplicity of the design of the vibratome.

FAQs

Hello Widget

What is a Compresstome®?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

Does the VF-510-0Z come with a warranty or service plan?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

What are the advantages of using a Compresstome vibrating microtome compared to other tissue slicers?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

What are the general steps for using the Compresstome to make tissue sections?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

What are the best cutting parameters to use for cutting speed and oscillation frequency?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

I get chattermarks on tissue slices. How can I achieve better slices?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

I am getting uneven tissue slices of inconsistent thickness. How do I fix this?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

What is the difference between the VF-210-0Z, VF-300, VF-510-0Z, and VF-800-0Z models?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

I want a fully automated model, should I choose the VF-300 or the VF-510-0Z model?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

What is a Compresstome®?

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut.

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

Precisionary Instruments Compresstome® tissue slicers are a type of vibrating microtome, otherwise known as a vibratome. We call ours the Compresstome® because our models utilize a patented compression technology that no other tissue slicer on the market possesses. This technology works by cutting samples vertically instead of horizontally. More importantly, it uses a specimen tube that embeds tissue samples in low-melting agarose. The sample then exits the tube, and the blade cuts the sample right at the site of compression, creating even, consistent slices every time you cut. 

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