Because PTCS requires is such a fine and delicate laboratory technique, obtaining healthy tissue slices with a high number of viable cells is crucial to successful experiments. The process of cutting brain slices also needs to occur rapidly, to prevent cell death. Therefore, the process requires a vibratome that can quickly make high quality precision-cut tissue slices without shearing cells on the surface.
The Compresstome® vibrating microtome has been used for almost 20 years in PTCS research, particularly for precision-cut lung slices. How does the Compresstome® vibrating microtome produces smooth, consistent precision-cut tissue slices? It does so by:
Dr Astero Klampatsa (PhD) is a Team Leader in Cancer Immunotherapy at the Institute of Cancer Research, London, UK and a Senior Lecturer in King’s College London, UK. She focuses on developing novel CAR T cell therapies for mesothelioma and lung cancer, as well as the immunobiology of these malignancies for identification of markers of response to immunotherapy. In this webinar, Dr. Klampatsa will discuss how the Compresstome® was used to create precision-cut tumor slices (PCTS) as an ex vivo model for immunotherapy research.
Visikol is a contract research services company focused on leveraging advanced imaging, 3D cell culture assays and digital pathology to accelerate the drug discovery and development process. In this webinar, Visikol explains the need for in vitro liver models to study livery injury. They demonstrate the standard assay format for creating precision-cut liver slices (PCLS), and explain how the Compresstome® VF-310-0Z vibrating microtome helps create uniform tissue slices that can be meaningfully compared between treatments. Visikol goes through how to use the Compresstome® step-by-step for making PCLS.
617-682-0586
