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Spatiotemporal Coordination of Stem Cell Behavior Following Alveolar Injury

Dr. Chioccioli:

  • Described motility of alveolar stem cells as a new injury response mechanism in the lung and reveal properties of stem cell motility at high cellular resolution
  • Explained early highly dynamic behavior of AT2 cells post injury, including migration within and between alveoli
  • Characterized the emergence of at least three distinct morphokinetic AT2 cell states associated with AT2 stem cell injury response
  • Shown how small molecule-based inhibition of Rho-associated protein kinase (ROCK) pathway significantly reduced motility of AT2 stem cells following injury and reduced expression of Krt8, a known marker of intermediate progenitor cells
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