Publication Highlight: Unmasking Treatment Vulnerabilities in a Rare Sinonasal Cancer Through Spatial Profiling and Ex Vivo Drug Testing
Key Takeaways Researchers profiled how SMARCB1-deficient sinonasal carcinoma responds to drugs directly in patient tumor tissue, preserving the spatial architecture rather than dissociating the sample. Live tumor slices were generated on a Compresstome tissue slicer, producing uniform, viable sections suitable for ex vivo drug exposure. Drug responses varied across distinct regions of the same tumor, […]