Compresstome® Lab Feature: The Madison Lab at Stanford University

As the number of Compresstome® vibratome users expand around the world, we would like to showcase some of their research work with you! This week, we feature the research of Professor Daniel Madison from Madison Lab at Stanford University.

The Compresstome® Vibratome in the Madison Lab:

The Madison lab prepares slices of rodent hippocampus and performs whole-cell ‘patch’ electrophysiology recordings from neurons in those slices.  In many cases, team members label those neurons by injecting fluorescent markers into them through the recording electrodes, or post-stain them with anti-bodies.  It is their aim to correlate the physiological and anatomical properties of these neurons to test specific hypotheses about neuronal function and synaptic plasticity. In a current series of experiments, the Madison lab is making slices from mouse neocortex using the Compresstome® VF-300-0Z vibratome to study the properties of myelin on inhibitory interneurons.

“We have only been using the new Compresstome for a few weeks, but have noted an immediate improvement in the quality of our brain slices,” reports Dr. Madison. “In particular, the slices have ‘cleaner’ surfaces and the neurons seem healthier.”

Madison Lab lab member
Lab member Dr. Marianna Kiraly preparing mouse hippocampal slices on our Compresstome.
Madison Lab TV screen
A photograph of a TV screen on Dr. Kiraly’s electrophysiological rig of the surface of the Compresstome®-prepared slices. The lab uses these TV images to target neurons for the electrophysiological electrodes.
Madison Lab volume reconstruction
A volume reconstruction image of a mouse hippocampal slice, taken from a YFP (yellow fluorescent protein) H-line mouse (green cells), also immunostained for DAPI (blue) and synaptophysin (red). Slice and photo credit: Dr. Ricardo Valenzuela, a former lab member.

To find out more about the Madison Lab at Stanford, visit:

Related Posts
Compresstome Vibrating Microtomes

Customer Testimonials at Precisionary Instruments

At Precisionary Instruments, we have almost two decades of customer service experience and microtome expertise. We have strategically built our brand to be trusted in


How sex hormones sculpt the brain

Sex hormones are hormones that play a role in the development and maintenance of the male and female reproductive systems, as well as secondary sexual

Compresstome Vibrating Microtomes

Introduction to Patch-Clamp Electrophysiology

Electrophysiology is the study of the electrical properties of biological cells and tissues, and how these properties generate and propagate electrical signals in the body.

Call Now Button617-682-0586