As the number of Compresstome® vibratome users expand around the world, we would like to showcase some of their research work with you! This week, we feature the research of Professor Daniel Madison from Madison Lab at Stanford University.
The Madison lab prepares slices of rodent hippocampus and performs whole-cell ‘patch’ electrophysiology recordings from neurons in those slices. In many cases, team members label those neurons by injecting fluorescent markers into them through the recording electrodes, or post-stain them with anti-bodies. It is their aim to correlate the physiological and anatomical properties of these neurons to test specific hypotheses about neuronal function and synaptic plasticity. In a current series of experiments, the Madison lab is making slices from mouse neocortex using the Compresstome® VF-300-0Z vibratome to study the properties of myelin on inhibitory interneurons.
“We have only been using the new Compresstome for a few weeks, but have noted an immediate improvement in the quality of our brain slices,” reports Dr. Madison. “In particular, the slices have ‘cleaner’ surfaces and the neurons seem healthier.”
To find out more about the Madison Lab at Stanford, visit:
Using precision-cut lung slices (PCLS) as an experimental model has revolutionized the study of respiratory diseases. PCLS offer a unique platform to investigate disease mechanisms,
The concept of using tissue slices to study organ metabolism and disease emerged in the 1920s, marking a significant milestone in the field of biomedical
You’ll hear back from us in one business day
© 2023 Copyright
*Academic discounts are only valid for customers in North America.
© 2023 copyright
617-682-0586
