Tag: pcls

New Protocol Guide: Everything You Need to Know About Precision-Cut Lung Slices (PCLS)

Explore our detailed manual for mastering PCLS in respiratory research We’re thrilled to announce the launch of our comprehensive Precision-Cut Lung Slices Protocol Manual—a practical, researcher-friendly guide designed to help you get consistent, healthy lung tissue slices every time. Whether you’re just getting started with PCLS or are looking for ways to refine your technique, this […]

Written by on April 25, 2025

Lab Spotlight: Dr. Gordon Jiang’s Lab at BIDMC

Pioneering RNA Therapeutics for Liver Diseases Dr. Gordon Jiang, a transplant hepatologist and physician-scientist at Beth Israel Deaconess Medical Center and Harvard Medical School, leads a research program focused on tackling some of the most challenging aspects of liver disease. His lab is dedicated to understanding the mechanisms behind liver failure—especially the role of transcriptional […]

Written by on April 14, 2025

precision-cut-lung-slices-3

Precision-cut lung slices #3: PCLS for specific respiratory disease research

Using precision-cut lung slices (PCLS) as an experimental model has revolutionized the study of respiratory diseases. PCLS offer a unique platform to investigate disease mechanisms, explore cellular and molecular interactions, and evaluate potential therapeutic interventions. With their preserved tissue architecture, cellular diversity, and physiological relevance, PCLS enable researchers to dissect complex respiratory pathologies, such as […]

Written by on September 18, 2023

Preparing and maintaining PCLS

Precision-cut lung slices #2: Preparing and maintaining PCLS

The concept of using tissue slices to study organ metabolism and disease emerged in the 1920s, marking a significant milestone in the field of biomedical research. Researchers recognized the immense value of preserving the structural integrity and functional properties of tissues by carefully slicing them into thin sections. This breakthrough technique allowed investigators to study […]

Written by on September 11, 2023

Translation model for studying lung disease

Precision-cut lung slices (PCLS) #1: Translation model for studying lung disease

Respiratory diseases have a profound impact on human health, making their study of paramount importance. These diseases, including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary infections, impose a significant burden on individuals and society as a whole. They can cause debilitating symptoms, reduce quality of life, and even lead to premature death. Moreover, respiratory […]

Written by on September 4, 2023